alexa Parvoviruses Infecting Captive And Wild Living Chimpanzees
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
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4th World Congress on Virology
October 06-08, 2014 Hilton San Antonio Airport, TX, USA

Brozova Kristyna, Hrazdilova Kristyna, Piel Alexander K, Stewart Fiona A, PetrzelkovaKlara J and Celer Vladimir
Posters: J Antivir Antiretrovir
DOI: 10.4172/1948-5964.S1.021
Parvoviridae family contains a group of small non-enveloped viruses with ssDNA genome containing 2 or 3 ORFsthat may infect large number of mammals including humans and primates.The most important and studied parvoviruses infecting primates and humans are genus Bocavirus, Erythrovirus B19 and Parvovirus 4 (PARV4). Antibodies against these viruses were previously detected in wild living primates. Bocavirus and PARV4 DNA was described in several cases in wild living chimpanzees and gorillas. Presence of antibodies and viruses itself in studied animals indicate frequent exposure. Although parvoviruses are often detected, no evidence of cross species transmission between people and primates has been described. In this study we analyze prevalence and the phylogenetic relationship of members of the Parvoviridae family in captive and wild living savanna-woodland chimpanzees(Pan troglodytes schweinfurthii) from Ugalla, Tanzania. Nested PCR with degenerated primers annealing in NS1 gene was performed on two sets of samples.The first set of fecal sampleswas obtained fromcaptive living chimpanzees (n=25), second one from wild living savanna-woodland chimpanzees (n=113). Using PCR, presence of Bocavirus DNA was confirmed in one captive living chimpanzee and in 13 wild living chimpanzee samples. Presence of PARV4 DNA was confirmed in one wild living chimpanzee sample. Our phylogenetic analysis of Bocavirus NS1 gene revealed two distinct groups ofbocavirusescirculating in wild chimpanzees, with the first group clustering with human bocavirus 1 (HBoV1), second one with HBoV3. The captive chimpanzee isolate is more related to human bocaviruses than those derived from wild living primates and raises a question of potential cross species transmission. Phylogenetic analysis of wild living chimpanzee PARV4isolate confirmedthe existence of aseparated group of wild primates PARV4isolates that form a distinct clade not related to any known human isolates. Thisworkwaspartiallyfunded by CEITEC CZ.1.05/1.1.00/02.0068, IGA 82/2014/FVL, OP VK CZ.1.07/2.3.00/20.0300 and OP VK CZ.1.07/2.3.00/30.0014.
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