alexa Pathological Evaluation And Reporting Of Intraductal Papillary Mucinous Neoplasms Of The Pancreas: The Correlation And Analyzes Of The Hispathotologic Patterns
ISSN: 2165-7092

Pancreatic Disorders & Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd Intenational Conference on Pancreatic Disorders & Treatment
September 13-14, 2017 Dallas, USA

Carolin Desire Nava Perez
Hospital Sirio Libanes, Brazil
Posters & Accepted Abstracts: Pancreat Disord Ther
DOI: 10.4172/2165-7092-C1-006
Abstract
Introduction: Papillary-mucinous neoplasms (IPMN) are a heterogeneous group of pancreatic tumors mucin-producing with uncertain biologic behavior. Nowadays, they can also be considered as a precursor of pancreatic carcinoma (PAC). Aim: The aim of this study is to analyze the IPMN subtypes distribution related with clinicopathological, histologic and immunohistochemical and to identify which one is more related to development of malignancy. Methods: This prospective study reports a 3-years follow up, with consecutive patients, where we analyzed the clinical findings, radiological aspects, and morphologic features in patient’s suspects of IPMN or PAC undergoing pancreatic surgery. The lesions were classified based on morphology and immunohistochemically defined by the current WHO criteria. Results: We analyzed 28 patients (16 women), mean age 66 y-old (range 50-83). 15 (53%) patients were asymptomatic, and 13 (47%) showed abdominal pain (8), chest pain (4), and recurrent acute pancreatitis (1). 10 patients were submitted to subtotal pancreatectomy, 9 to duodenopancreatectomy, 7 to gastroduodenopancreactectomy, 2 subtotal pancreatectomy and splenectomy. The neoplasm was located in head, body and tail, and entire pancreas in 18, 9, and 1, respectively. 14 patients (50%) had involvement of the main pancreatic + branch ducts (mixed type), 7 (25%) had only the main pancreatic duct involved, 6 (21.5%) had only the branch-duct involved, and 1 (3.5%) had not informed. The mean size of the lesion was 3.3 cm + 6.1 (1-11 cm). Morphological features showed multi-loculated (23) solid-cystic (4) and solid (1). MUC1, MUC5AC, and MUC2 immunohistochemically expressed in 18 (64%), 17 (61%), and 11 (39%), respectively. The hispathotologic patterns founded was gastric-type (9), intestinal-type (3), pancreatobiliary-type (9), mixed-type [6 (Pb-t + I-t (4), and Pb-t + G-t (2)), and oncocytic-type (1). The IPMN with a low-grade, and high-grade dysplasia and invasive carcinoma was found in 18 (64.2%), 6 (21.5%) and 4 (14.2%), respectively. We observed that all pancreatic intraepithelial neoplasia (PanIN) founded was related to Pbt 13 (46%). The invasive PAC was presented in 4 patients (14,2%) with the following subtypes (Pb-t (2), and Pb-t + I (1)), and colloid PAC [I-t (1)]. Was found a synchronic neoplasia in 2 patients (colon adenocarcinoma, and NET). Conclusion: IPMN of the pancreas is a common cystic lesion located more frequent on both duct (mixed-type). showing more aggressive behaviour than other patterns. Pb-t was the most common lesion and was more connecting to invasive PAC and HGD, as well as connected with PanIN. Prospective studies are needed to confirm these findings.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords