alexa PERCEPTION OF ORAL ANTIDIABETIC AGENTS ADVERSE EVENTS AND THEIR IMPACT ON HEALTH RELATED QUALITY OF LIFE IN TYPE 2 DIABETIC PATIENTS | 69417
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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18th European Diabetes Congress

Rui Santos Cruz, Luiz Miguel Santiago and Carlos Fontes Ribeiro
Polytechnic Institute of Coimbra, Portugal
University of Beira Interior, Portugal
University of Coimbra, Portugal
Posters & Accepted Abstracts: J Diabetes Metab
DOI: 10.4172/2155-6156-C1-067
Abstract
Currently, drug therapy with oral antidiabetic agents, is capable of inducing normoglycemia levels able to decrease the risk of complications associated with diabetes mellitus. However, it is also known that the various existing oral antidiabetic agents may trigger a large number of adverse events, either alone or in combination. Some of these tolerability and security issues related to the oral antidiabetic are reported by patients and can influence negatively or satisfaction with treatment or glycemic control, or the therapeutic adherence and maintenance. It is therefore, very important the role of patients in monitoring of adverse events related to the use of the oral antidiabetic drugs in order to optimize treatment and improve the quality of life of patients with type 2 diabetes (DM2). The aim of this study is to determine the prevalence of adverse events associated with the use of oral anti-diabetics and assessing their impact on health-related quality of life (HRQoL) of diabetic patients tracked in primary health care. A total of 357 DM2 patients were enrolled in observational and cross-sectional study, recruited in six Health Care Centers and Family Health Units (FHU) of the central region of Portugal. The data collection comprises three questionnaires to measure the prevalence of adverse events, the diabetes health profile (DHP-18) and EQ-5D-3L. The results show that the highest prevalence of adverse events is in the dipeptidyl peptidase-4 inhibitors followed by metformin+sitagliptin (fixe dose) and metformin+vildagliptin (fixe dose) therapeutic classes. We also found that all the correlations between different variables are statistically significant (p<0.001). Thus, we conclude that patients who show greater number of adverse events tend to have poorer health profile, worse general health and also lower health related quality of life.
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