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Pharmacodynamics Of Rofecoxib Following Topical Administration In Rat | 8273
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

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Pharmacodynamics of rofecoxib following topical administration in rat

2nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit-2011 and International Conference on Pharmaceutics & Novel Drug Delivery Systems

Malay K Das and Abdul B Ahmed

Special Issue BABE-2011: Posters: JBB

DOI: 10.4172/0975-0851.1000105

T he potential gastrointestinal (GI) disorders associated with oral administration of rofecoxib can be avoided by delivering the drug to the infl ammation site for sustained therapeutic action. Hyroxypropyl methylcellulose (HPMC), Sodium alginate and Carbopol 940 were used to develop topical gel of rofecoxib. Rofecoxib encapsulated niosomes were prepared by lipid fi lm hydration technique. Th e niosomal vesicles obtained were incorporated into blank carbopol gel to form niosomal gel. Th e eff ects of diff erent variables on rofecoxib permeation from gel formulation was evaluated using cellulose membrane, rat epidermis and pig ear epidermis mounting on a Keshary-Chien glass diff usion cell. Th e anti-infl ammatory activity of rofecoxib gel was evaluated using carrageenan-induced rat hind paw edema model. Th e niosomal gel showed a prolong drug release behavior as compared to plain drug gel. Th e diff erential scanning calorimetric study of drug loaded gel and pig epidermis aft er permeation study confi rmed the inertness of the carbopol gel base towards rofecoxib and absence of drug metabolism in the skin during permeation study, respectively. Th e anti-infl ammatory activity of 4% w/w sodium alginate-carbopol 940 gel containing 25 % w/w rofecoxib in the rat hind paw edema model reveals that rofecoxib was delivered to the infl ammation site at a controlled level over a period of 6 h. Th ese results suggest the feasibility of topical administration of rofecoxib with avoidance of major GI disorders associated with peroral rofecoxib.
Dr. Malay K Das has completed his Ph. D. degree from Jadavpur University, Kolkata, India. He is currently serving as Assistant Professor (Pharmaceutics) in the Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, India. He has supervised 16 M. Pharm. thesis and 5 Ph. D. theses yet to be submitted under his guidance. He has published more than 20 research papers in various national and international journals