he potential gastrointestinal (GI) disorders associated with oral administration
of rofecoxib can be avoided by delivering the drug to the infl
for sustained therapeutic action. Hyroxypropyl methylcellulose (HPMC), Sodium
alginate and Carbopol 940 were used to develop topical gel of rofecoxib. Rofecoxib
encapsulated niosomes were prepared by lipid fi
lm hydration technique. Th
vesicles obtained were incorporated into blank carbopol gel to form niosomal gel.
ects of diff
erent variables on rofecoxib permeation from gel formulation was
evaluated using cellulose membrane, rat epidermis and pig ear epidermis mounting
on a Keshary-Chien glass diff
usion cell. Th
ammatory activity of rofecoxib
gel was evaluated using carrageenan-induced rat hind paw edema model. Th
niosomal gel showed a prolong drug release behavior as compared to plain drug gel.
erential scanning calorimetric study of drug loaded gel and pig epidermis aft
permeation study confi
rmed the inertness of the carbopol gel base towards rofecoxib
and absence of drug metabolism in the skin during permeation study, respectively. Th
ammatory activity of 4% w/w sodium alginate-carbopol 940 gel containing 25
% w/w rofecoxib in the rat hind paw edema model reveals that rofecoxib was delivered
to the infl
ammation site at a controlled level over a period of 6 h. Th
ese results suggest
the feasibility of topical administration of rofecoxib with avoidance of major GI
disorders associated with peroral rofecoxib.
Dr. Malay K Das has completed his Ph. D. degree from Jadavpur University, Kolkata,
India. He is currently serving as Assistant Professor (Pharmaceutics) in the Department of
Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, India. He has supervised 16 M.
Pharm. thesis and 5 Ph. D. theses yet to be submitted under his guidance. He has published
more than 20 research papers in various national and international journals
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