ulathromycin is a novel long-acting semi-synthetic macrolide antibiotic of the
triamilide group that is used in the treatment of respiratory diseases in cattle
and pigs. Th
e pharmacokinetics of tulathromycin were determined in fi
goats following single intravenous and intramuscular injections of 2.5 mg/kg BW
with a 6 week interval between injections. Plasma, milk and urine concentrations of
tulathromycin were determined using a microbiological assay method.
Following a single intravenous injection of tulathromycin formulation, the
concentration-time curves were best described by a two compartment open model.
Tulathromycin had a high volume of distribution (V
, 16.1 ? 2.0 L/kg) and was
slowly cleared from the central compartment (126 ? 4 ml.kg
). Tulathromycin was
detected in the milk of goats 30 minutes aft
er IV injection with mean concentration
of 0.15 ? 0.03 μg.ml
and persisted for 21 days over target MIC. Tulathromycin was
detected in the urine from 0.5 to 96 hours aft
er IV injection and exceeded the target
for 14 days hours post injection. Plasma protein binding was 22.8%.
Following a single intramuscular injection of tulathromycin formulation, the
maximum plasma concentration (0.73 ? 0.07 μg.ml
) was reached at 0.5 hour and
detectable tulathromycin concentrations were present in the plasma for up to 168
hours. Tulathromycin was rapidly absorbed (t
, 0.104 ? 0.02 hour) and slowly
, 99.4 ? 11.2 h.) aft
er IM injection. Th
e calculated MRT
? 21.9 h and bioavailability was 95.8 ? 6.5%. Tulathromycin rapidly penetrated into
milk with high C
ratio and AUC
persisted in urine samples for 13 days post-injection.
Aziza Mahrous Amer has completed her Ph. D at the age of 26 years from Cairo University
and postdoctoral studies from Cairo University. She is Professor of Pharmacology, Faculty
of Veterinary Medicine Cairo University. She has published more than 50 papers in reputed
journals and serving as an editorial board member of repute. The areas of reseaches are
Pharmacokinetics ? Pharmacodynamics Pharmacokinetic interactions, Evaluation of new drug
of plants and natural origin.
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