alexa Phenotypical Analysis Of Ectoenzymes CD39 And CD73 In Peripheral Blood CD4+CD25highFoxp3+ Regulatory T Cells In Psoriasis
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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9th World Dermatology & Pediatric Dermatology Congress
October 10-11, 2016 Manchester, UK

Ling Han and Qiong Huang
Huashan Hospital, China
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554.C1.042
It is currently unclear whether human ectoenzymes (CD39/CD73) involved in the impaired suppressive activity of CD25high Foxp3+ regulatory T cells (Tregs) in psoriasis. This stidu aimed to evaluate the frequency and phenotypes of CD39/CD73- expressing Tregs and related receptor adenosine receptor 2A (A2AR) in peripheral blood of patients with different types of psoriasis. Peripheral blood mononuclear cells (PMBCs) were prepared from patients with three different types of psoriasis (psoriasis vulgaris, pustular psoriasis and erythrodermic psoriasis) and the frequency and phenotypes of CD39 and CD73 expressing Tregs, A2AR expressing Teff were all determined by flow cytometry analysis. Blood from healthy volunteers served as controls. At approximately 50% less than that of normal controls, the expression of single CD73+Tregs was markedly reduced in psoriasis vulgaris patients. Additionally, the levels of CD39+Tregs and A2AR+Teff in pustular psoriasis were significantly lower than in normal controls. Among three different types of psoriasis, CD39 expression was strikingly reduced in the blood Treg population of pustular psoriasis patients. Decreased CD73+Tregs level were observed in psoriasis vulgaris compared to pustular psoriasis and erythrodermic psoriasis patients. The differences in the expression of CD39- and CD73-Tregs may be a factor in the pathogenesis of psoriasis.

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