Journal of Nanomedicine & Nanotechnology

pH-Responsive theranostic nanocomposites as synergistically enhancing positive and negative magnetic resonance imaging contrast agents

15^th World Medical Nanotechnology Congress

October 18-19, 2017 Osaka, Japan

Shizhen Chen, Xi Huang and Yuqi Yang

Chinese Academy of Sciences, China

Scientific Tracks Abstracts: J Nanomed Nanotechnol

Abstract:

The rational design of theranostic nanocomposite exhibiting synergistic turn-on of therapeutic potency and enhanced diagnostic imaging in response to tumor milieu is critical for efficient personalized cancer therapy. We here in fabricate a theranostic nanocomposites Mn-porphyrin&Fe3O4@SiO2@PAA-cRGD, which could synergistically enhancing positive and negative magnetic resonance imaging signals for both accurate tumor imaging and pH-responsive drug release. Fluorescent imaging also showed that the nanocomposite specifically accumulated in lung cancer cells by a receptor-mediated process, and were nontoxic to normal cells. The r2/r1 ratio varied is 20.6 in neutral pH 7.4 , r2/r1 ratio 7.7 in acidic pH 5.0, which suggesting the NCs could act as an ideal T1/T2 dual-mode contrast agents at acidic environments of tumor areas. For in vivo MRI, T1 and T2 relaxation was significantly accelerated to 55% and 37%, respectively, in the tumor after i.v. injection of nanocomposites. The results demonstrate great potential of such nanocomposites for real-time imaging with greatly enhanced diagnostic accuracy during targeted therapy.

Biography :

Shizhen Chen received her PhD in 2011 from Central China Normal University, and then began her post-doctoral research at Wuhan Institute of Physics and Mathematics. In 2013, she became an associate professor. Dr. Chen’s work focuses on magnetic resonance imaging (MRI) contrast agents, especially concentrated on the nanomaterial-based MRI contrast agents for lung cancer imaging.