alexa Physicochemical And Mechanical Evaluation Of A Novel Theophylline And 4-aminobenzoic Acid Pharmaceutical Co-crystals
ISSN: 2169-0022

Journal of Material Sciences & Engineering
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

9th World Congress on Materials Science and Engineering
June 12-14, 2017 Rome, Italy

Rahamatullah Shaikh, Denise Croker and Gavin M Walker
University of Limerick, Republic of Ireland
Posters & Accepted Abstracts: J Material Sci Eng
DOI: 10.4172/2169-0022-C1-068
Statement of the Problem: Pharmaceutical cocrystals are solids that are crystalline materials comprise of two or more components held together by non-covalent forces. In recent years co-crystals are being studied intensively due to the potential for improved pharmaceutical properties such as increased solubility, bioavailability, chemical stability and hygroscopicity of active pharmaceutical ingredients. A crystalline particle is characterized by definite crystal habit which relates to the external structure (such as shape and size) and crystal lattice describes the internal structures. Change in crystal forms has significant effect on drug particle mechanical properties (particle strength, flowability, miscibility and tableting) dissolution rate and stability. To enhance understanding of cocrystallization process on mechanical properties of Theophylline (active pharmaceutical ingredient) in the present study the impact of crystal structure and its relationship with powder compaction has been investigated. Methodology: Novel theophylline and 4-aminobenzoic acid pharmaceutical co-crystals at molar ratio of 1:1 were synthesized by solvent evaporation and mechano-chemical synthesis techniques. Co-crystals were mainly characterized by powder X-ray diffraction (PXRPD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR) and single crystal X-ray diffraction. Theophylline cocrystals were also subjected to powder flow, powder compaction and relative humidity stability testing studies. Findings & Significance: The molecular structure of the novel theophylline and 4-aminobenzoic acid pharmaceutical cocrystal was further confirmed using single crystal X-ray diffraction analysis. Finally crystal structure and its relationship can be considered for improving mechanical properties of API.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version