alexa Phytochemical Analysis And Preliminary Pharmacological Evaluation Of Horse Apple As A Sustainable Source For Bioactive Isoflavones
ISSN: 2329-6836

Natural Products Chemistry & Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference and Exhibition on Pharmacognosy, Phytochemistry & Natural Products
August 25-27, 2014 DoubleTree by Hilton Beijing, China

Ehab A Abourashed, Shabana I Khan and Aida Abraha
ScientificTracks Abstracts: Nat Prod Chem Res
DOI: 10.4172/2329-6836.S1.002
Abstract
The fruit of Maclura pomifera tree (Raf.) Schneid. (family Moraceae), commonly known as horse apple, has traditionally been used as an insect repellant and its extract is a strong antioxidant. The major constituents of horse apple are the prenylated isoflavones pomiferin and osajin which are responsible for its antioxidant activity as well as other activities, such as cardioprotective and antitumor effects. The tree grows in Southern United States and the Midwest and produces its fruits in abundance during late summer and fall making it a rich and sustainable source for medicinally useful natural products. The first goal of this project was to identify horse apple sources and the best sample preparation procedures leading to extracts with high isoflavone content. The second goal was to investigate the activity of horse apple in new targets for certain disease conditions. To achieve the first goal, a reversed-phase HPLC method was developed, validated and applied to determine the effect of geographical location, degree of development and sample preparation on the levels of pomiferin and osajin in horse apple. For the second goal, the total methanolic extract was evaluated in two panels of in vitro assays for anti-inflammatory activity (inhibition of iNOS and NF-kB/induction of NAG), and inhibition of tau protein fibrillation. Phytochemical analysis indicated that the isoflavone content in horse apple may exceed 5% of dry weight and that the degree of maturity of the fruit hasa significant effect on its isoflavone content. Some promising results were also obtained from the preliminary in vitro evaluation of the total extract.
Biography
Ehab A Abourashed graduated with a Bachelor of pharmaceutical sciences at Cairo University, Egypt. He obtained his Masters and PhD degrees from the Universities of Tennessee and Mississippi, respectively. He worked as senior scientist at GlaxoSmithKline and director of quality assurance at ElSohly Labs, USA. He was a faculty member at King Saud University prior to joining the College of Pharmacy at Chicago State University. He has more than 80 publications and presentations on natural products isolation, structure determination and microbial transformation as well as phytochemical, biochemical and environmental analysis. He is a member of many professional and honor societies.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords