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Nanotechnology has revolutionized management of infections and infestations as it has turned chemicals of previously little
or no clinical benefits to potent instruments for treatment of infections in humans. This study was set up to review the
phytochemistry of Ganoderma applanatum, its potentiality in nanotechological engineering for clinical use as well as impact of
aqueous extracts of Ganoderma applanatum on laboratory rats infected with Trypanosoma brucei brucei. Aqueous extracts of
Ganoderma applanatum were obtained using hot sterile distilled water through whatmann filter paper. The presence of saponins,
alkaloids, tannins, anthraquinones, flavonoids, cardiac glycosides and steroids were tested using standard procedures in vitro.
Laboratory rats were infected with Trypanosoma brucei brucei by injecting infected blood samples into their peritoneal cavities.
Laboratory rats infected with Trypanosoma species served as positive controls while similar sets of rats uninfected by the parasites
served as negative controls. Acqueous extracts were then inoculated through the tail veins into laboratory rats infected with
Trypanosoma brucei brucei along with the negative controls. Blood samples were collected daily, stained with Giemsa?s stain
and examined under X100 oil immersion objective lens using the microscope for the presence of Trypanosoma brucei parasites.
Ganoderma applanatum aqueous extracts contained detectable levels of saponins, flavonoids, cardiac glycosides and steroids but
undetectable levels of alkaloids, tannins and anthraquinone. All the infected rats died by day 12 from overwhelming trypanosomal
infections due to its obvious lack of activity.The biochemical constituents of Ganoderma species should be subjected to further
research probably nanotechnological engineering in order to, perhaps, discover more of its wider therapeutic benefits, and to
further disprove its suitability or otherwise in the treatment of African sleeping sickness.
Joysree Das has been working as a Assistant Professor, in the Department of Pharmacy, BGC Trust University, Bangladesh from July 2012 to till
the date. Mrs. Das has published more than 20 research and review papers in reputed International and national Journal. She participated in many
seminars and conferences in home to present his research activities. Her research work based on Phytochmistry, Pharmacology, Molecular biology,
Oncology and Bioinformatics. She is a life member of Association of Pharmacy Professionals (APP), India. Shee is interested in Clinical Pharmacy,
Protein Engineering, Immunology and Molecular Medicine.
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