alexa Plants With Antidiabetic Activity; Mechanisms Of Action
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

16th Global Diabetes Conference & Medicare Expo
March 22-23, 2017 Rome, Italy

Zafar H Israili and Ayesha Farooqui
Emory University School of Medicine, USA
ScientificTracks Abstracts: J Diabetes Metab
DOI: 10.4172/2155-6156.C1.063
Diabetes, one of the most common endocrine metabolic disorder (285 million diabetics), affects the eyes, kidney, brain, heart, limbs and the nervous system. Presently available antidiabetic drugs (insulin, sulfonylureas, biguanides, thiazolidinediones, GLP- 1 mimetics/analogs, DPP-4 inhibitors, meglitinides, amylin analogs, SGLT2 inhibitor and α-glucosidase/aldolase/reductase/amylase inhibitors) become less effective over time and also have safety and tolerability issues. Worldwide about 800-1200 plants (herbs) reported to be used to treat diabetes, are low cost, readily available, and perceived to be non-toxic. The mechanisms of hypoglycemic action of many of these plants are similar to those of the conventional antidiabetic agents: 1) Insulin-like activity (Cinnamomum cassia/C. zeylanicum, etc.); 2) Insulinotropic effect (Stevia rebaudiana Bertoni); 3) Insulin sensitization (Momordica charantia, S. rebaudiana Bertoni, Synsepalum dulcificum); 4) Induction of insulin-like glucose transport into adipocytes (Lagerstroemia speciosa); 5) Alpha-glucosidase inhibition {Acosmium panamense (Benth.), M. charantia]; 6) Aldolase reductase inhibition (Cecropia obtusifolia Bertol., Fructus Arctii); 7) Alpha-amylase (pancreatic) inhibition (Azadirachta indica, Eugenia jambolana); 8) Liver gluconeogenesis inhibition (M. charantia and S. rebaudiana); 9) Increasing GLP-1 binding to receptor (Artemisia dracunculus L.); 10) PPAR-γ agonist (Punica granatum, Vaccinium angustifolium Aiton.); 11) Dual-PPAR-α/γ agonist activity (P. granatum); 12) Inhibition of sodiumdependent glucose cotransporter-2 (Nigella sativa seeds); 13) Inhibition of acetyl-CoA carboxylase (Persea americana Mill); 14) Activation of AMP-activated protein kinase (M. charantia), etc. Shortcomings of plant medicine include, diagnosis and therapeutic effectiveness mostly based upon symptoms and relief of symptoms, lack of standardization for quality, dosing, and efficacy, and toxicity may ignored or not recognized.

Zafar H Israili has completed his PhD in Medicinal Chemistry from the University of Kansas and has completed his training in Clinical Pharmacology from Emory University School of Medicine (EUSM). He is an Associate Professor of Medicine at EUSM and an Adjunct Professor of Chemistry at Georgia State University. He is also a Visiting Professor at the University of Fez, Morocco. He has work experience as an Adjunct Professor in Chemistry at the Emory University; Adjunct Professor in Pharmacology at Morehouse School of Medicine and as a Research Pharmacologist at Veterans Administration. He is an Associate Editor of Journal of Hypertension; Latin American Journal of Hypertension and Guest Editor of International Journal of Hypertension. Previously, he was the Editor of Ethnicity and Disease, Associate Editor/Editorial Board Member of Drug Metabolism Reviews and Drug Development Research. He is a reviewer for more than 60 medical- and scientific journals. He has published 177 research papers, reviews and book chapters.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version