Reach Us +1-504-608-2390
Plasmodium Vivax Tryptophan-rich Antigens | 3262
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Plasmodium vivax tryptophan-rich antigens

Y.D.Sharma, Md. Zeeshan, Rupesh Tyagi and Hema Bora

: J Vaccines Vaccin

Plasmodium vivax is a non-cultivable human malaria parasite which is highly prevalent in Southeast Asia. There is no vaccine available for this parasitic disease. This requires the identification and immunological characterization of potential vaccine target molecules of this parasite. In this regard, we have reported several P.vivax tryptophan-rich antigens (PvTRAgs) whose counterparts in murine malaria are important vaccine candidates. In the present study, we have investigated humoral and cellular immune responses to fifteen different PvTRAgs among P.vivax exposed and healthy controls. A significantly higher level of CD69 expression was observed against all these 15 antigens among P. vivax exposed individuals as compared to uninfected healthy controls. Some of these antigens showed better response than the others. The intracellular cytokine profile against these antigens showed higher levels of IL-2, IFN-gamma and IL-4, as compared with IL-10 levels in CD4+ T cells of P.vivax exposed individuals. Naturally acquired antibody against these antigens was significantly higher in P.vivax exposed individuals than healthy controls. These proteins show very little genetic variation in the parasite population. Six of these 15 proteins showed binding to the host erythrocyte. In conclusion, all PvTRAgs show very little genetic variation, a higher sero-positivity rates, and both Th1 and Th2 responses.