alexa PLGA Based Nanoparticles As Protein Carriers: Radiolabeled Protein Delivery System | 70097
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

13th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology

Mona Kabiri, Mohsen Tafaghodi, Mojtaba Sankian, Kayvan Sadri and Johannes Oldenburg
Student Research Committee, Mashhad University of Medical Science, Iran
Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Science, Islamic Republic of Iran
Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Germany
Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Iran
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Iran
Posters & Accepted Abstracts: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439-C1-050
Abstract
Among the novel delivery systems, polymeric nanoparticles have been considered as promising carriers for therapeutic applications. The use of biocompatible and biodegradable polymers such as Polylactic-Co-Glycolic Acid (PLGA) as protein and drug carriers has long been of interest in controlled-release technology. PLGA nanoparticles act as potential carriers for several classes of lipophilic and hydrophilic drugs such as anticancer agents, immunomodulators and hormones, as well as macromolecules including nucleic acids, proteins, peptides, and antibodies. The PLGA nanoparticles were prepared by water-in-oil-in-water (w/o/w) (double emulsion) method. In this method, the aqueous protein solution (BSA) was added to the PLGA organic solution. The mentioned method is best suited to encapsulate water-soluble drugs like peptides, proteins and vaccines. The nanoparticles were characterized in terms of particle size, poly dispersity index (PDI) and zeta potential, as well as entrapment efficiency of I-125 labeled BSA. Furthermore, particle morphology and size are determined with scanning electron microscopy (SEM). As estimated by dynamic light scattering (DLS), the mean size of the PLGA nanoparticles were about 150 nm and 185 nm (n=5) for blank PLGA and PLGA-BSA after lyophilization, respectively. Also, The DLS analysis indicated a unimodal particle size distribution, with PDI of 0.2 and zeta potential of -38 mV. PLGA polymers were non porous, smooth surfaced and spherical in structure under SEM with a mean particle size ranging from 70 to 100 nm. The loading efficiency of the radiolabeled protein in PLGA nanoparticles was 91.2%. Radiolabeled protein encapsulated in PLGA nanoparticles can be useful for therapeutic projects.
Biography

Mona Kabiri is a PhD Candidate of Pharmaceutical Nanotechnogy at School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. She is a Guest Researcher at Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany. She finished her PhD thesis about protein vaccine delivery system based on PLGA polymeric nanoparticles and nano-adjuvants. She has published three articles in ISI journals and has three national and US-patents.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

kactakapaniyor.com

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

Taktube

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

sikiş

[email protected]

1-702-714-7001Extn: 9037

instafollowers

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

putlockers

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

seks

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version