alexa PMLA Nanoconjugates For Effective Delivery Of Antisense Oligos: Optimization, Mechanism, And Brain Tumor Treatment
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th International Conference on Nanotek & Expo
December 01-03, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Hui Ding
ScientificTracks Abstracts: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439.S1.017
Abstract
Polymalic acid (PMLA) is a naturally occurring biodegradable polymer suitable for drug delivery. In order for PMLA copolymers to deliver antisense oligos into cyteoplasm, they must acquire the capability to cross the cytoplasm membrane. We designed and synthesized dozens of PMLA copolymers, and found PMLA copolymers of leucine ethyl ester (P/LOEt) or trileucine (P/LLL) show either pH-independent or pH-dependent activity for membrane penetration. The two copolymers displayed distinctly different properties in solution and during membrane permeation: P/LOEt binds extensively to membrane causing permeation through a ?carpet? model; in contrast, P/LLL self-assembles to form oligomers pH-dependently (pKa 5.5) and induces membrane pores through a ?barrel-stave? model. Both copolymers were selected for the delivery antisense oligos for the treatment of glioma. Malignant gliomas are the most aggressive and lethal brain tumors. Currently, effective glioma treatment drugs are still very limited. Nanoconjugates based on membrane permeant PMLA copolymers P/LLL and P/LOEt were synthesized for glioma treatment. The nanoconjugates were designed to bypass two major barriers, brain tumor barrier (BTB) and tumor cell membrane, containing three key functional components: monoclonal antibodies to transferrin receptor; cleavable antisense oligonucleotides (AONs) for inhibition of laminin-411 synthesis; and membrane permeable endosome escape unit. They demonstrated efficient cytoplasmic delivery of AON for significant inhibition of laminin-411 synthesis in vitro and in vivo, specific accumulation in brain tumor cells, inhibition of tumor angiogenesis and effective suppression of intracranial glioma growth.
Biography
Hui Ding has extensive research experience in drug delivery, biomaterials, and cancer treatment. He received his BS from Beijing Medical University and completed his PhD in the Department of Pharmaceutics and Pharmaceutical Chemistry at the University of Utah in 2006. He started his post doctoral research in the Department of Neurosurgery at Cedars-Sinai Medical Center working on the brain and breast tumor treatment using polymalic acid as drug delivery system. He continued his research on drug delivery and naomedicine as research scientist after 2010 and assistant professor after 2012 at Cedars-Sinai.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords