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Polybutyleneadipate-co-terephthalate (PBAT) is aliphatic-aromatic co-polyester based on the monomers 1, 4-butanediol, adipic
acid and terephthalic acid. Recently, it has been considered as a promising biomaterial for tissue engineering applications
due to its non-toxicity, desiredphysical properties and complete biodegradability under enzymatic conditions. However, existing
studies are limited to cytotoxicity and basic cell proliferation assays with non-functional PBAT membranes which is not enough to
understand PBAT?s behavior as scaffolds for tissue regeneration. In this study, 2D and 3D porous PBAT scaffolds were fabricated via
solvent casting, electro-spinning, solvent casting-particulate leaching and melt molding-particulate leaching methods. Fabricated
scaffolds were characterized due to their morphologies, mechanical properties, water absorption capacities, wettabilities and preosteoblastic
cell promotion in order to estimate its potential for tissue regeneration. PBAT scaffolds were successfully fabricated in
various structural forms with up to 90% porosities. Attachment and proliferation of MC3T3-E1 pre-osteoblastson PBAT surfaces
was observed with scanning electron microscope (SEM) on the 4th, 24th hours, 3rd and 11th day of cell culture. Results show
that cells favored the neat PBAT surfaces in all fabricated structural forms. At the 11th day of the cell culture, PBAT surfaces were
covered by cells and extracellular matrix secreted by the cells. As a result, it is easy process ability, good mechanical properties,
biocompatibility and well-known biodegradability makes it a powerful candidate for tissue engineering applications. In further
studies, tissue engineering potentials of neat and modified 3D electrospun PBAT scaffolds will be investigated.
Aysu Arslan has completed her BSc degree from Hacettepe University, Department of Chemical Engineering. Currently she is MSc student at the same department
and she is a Member of Hacettepe University Cell and Tissue Engineering Research Group, being coordinated by Prof Dr Menemse Gumusderelio?lu. She has
published 1 paper in a related journal.
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