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During the process of ethanol production from sugarcane, a number of carbonaceous compounds in the form of particulate
matter along with the polycyclic aromatic hydrocarbons (PAHs) are introduced in the atmosphere. The particulate matter,
including PAHs causes DNA damage which involve DNA double- strand breaks (DSBs) as well as single strand breaks (SSBs).
DNA damage, either double strand break or single strand break leads to mutation which may be a probable cause for developing
lung cancer. The first step in the initiation of activity of DNA damage checkpoints is recognition of DNA damage. Components
of checkpoint mechanism include sensors, mediators, transducers and effectors which work cooperatively in different phases of
cell cycle. Once DNA damage is sensed, the apical kinases ATM and ATR become activated, which, in turn, phosphorylate several
substrates leading the signaling pathway to G1/S and G2/M arrests, respectively. Since, checkpoint kinase 2 and checkpoint
kinase 1 play crucial roles in the progression of these signaling pathways leading to G1/S and G2/M arrests. The inhibition
of checkpoint kinases 2 and 1 could abrogate the G1/S and G2/M arrests, respectively, which could be proved useful in the
therapeutics of anticancer drug development. Thus, the inhibition of checkpoint kinases 2 and 1 could be the ideal candidate
targets for anticancer drug development.
Polycyclic aromatic hydrocarbons, ATM, ATR, checkpoint kinase.
I received a Bachelor of Science from Kumaun University, Nainital, India and Master of Science in Biotechnology from Amity University, Noida, India.
Currently,I am working as a Project Assistant in Amity Institute for Herbal Research and Studies at Amity University, Noida, India.
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