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Polycyclic Aromatic Hydrocarbons Could Trigger The Deregulation Of Cell- Cycle Signaling Pathways Leading To Lung Cancer | 3340
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Polycyclic aromatic hydrocarbons could trigger the deregulation of cell- cycle signaling pathways leading to lung cancer

Ravendra P.S. Chauhan, Charu Gupta and Dhan Prakash

: J Vaccines Vaccin

During the process of ethanol production from sugarcane, a number of carbonaceous compounds in the form of particulate matter along with the polycyclic aromatic hydrocarbons (PAHs) are introduced in the atmosphere. The particulate matter, including PAHs causes DNA damage which involve DNA double- strand breaks (DSBs) as well as single strand breaks (SSBs). DNA damage, either double strand break or single strand break leads to mutation which may be a probable cause for developing lung cancer. The first step in the initiation of activity of DNA damage checkpoints is recognition of DNA damage. Components of checkpoint mechanism include sensors, mediators, transducers and effectors which work cooperatively in different phases of cell cycle. Once DNA damage is sensed, the apical kinases ATM and ATR become activated, which, in turn, phosphorylate several substrates leading the signaling pathway to G1/S and G2/M arrests, respectively. Since, checkpoint kinase 2 and checkpoint kinase 1 play crucial roles in the progression of these signaling pathways leading to G1/S and G2/M arrests. The inhibition of checkpoint kinases 2 and 1 could abrogate the G1/S and G2/M arrests, respectively, which could be proved useful in the therapeutics of anticancer drug development. Thus, the inhibition of checkpoint kinases 2 and 1 could be the ideal candidate targets for anticancer drug development. Keywords: Polycyclic aromatic hydrocarbons, ATM, ATR, checkpoint kinase.
I received a Bachelor of Science from Kumaun University, Nainital, India and Master of Science in Biotechnology from Amity University, Noida, India. Currently,I am working as a Project Assistant in Amity Institute for Herbal Research and Studies at Amity University, Noida, India.