alexa Polymalic Acid: Biology And Drug Delivery
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

3rd International Conference on Nanotek & Expo
December 02-04, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Eggehard Holler
ScientificTracks Abstracts: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439.S1.013
Polymalic acid is a highly water soluble polyanion synthesized by the slime mold Physarum polycephalum for managing the synchrony of nuclear divisions in the growing polynucleated plasmodium. Alternating binding of replicative DNA polymerases and newly synthesized histones together with trafficking between nuclei are considered fundamental in the maintenance of the synchronous division cycle. Massively in excess produced polymer is highly purified from the culture medium and used as nanoscale platform for drug delivery. Being biodegradable, non-toxic, non-immunogenic, the polymer optimally qualifies as a nanoparticle platform. The polymer offers a large number of reactive carboxylates (900 per polymer of Mw 100,000) and a highly flexible architecture. A variety of interesting molecules such a chemotherapeutics, antisense oligonucleotides, proteins, peptides and polyethylene glycol (PEG) are covalently attached for targeted drug delivery, but also fluorescent molecules and DOTA-gadolinium(III) have been conjugated for imaging. Methods of physical, chemical and functional group analysis of the pharmaceutically pure all-in-one covalent nanodrug have been established, and biocompatibility including cytotoxicity and immunogenicity has been demonstrated in vitro and in vivo . All-in-one covalent contrast agents show favorable biodistribution by fluorescence and magnetic resonance imaging (MRI) and have been used for diagnosis of brain tumors in animal models. Delivery of drugs as inactive prodrugs and their activation at the site of treatment render the all-in-one covalent nanodrug a highly efficient and secure treatment modality.
Eggehard Holler has completed his Ph.D. at the age of 27 years from Johann-Wolfgang Goethe University at Frankfurt/Main, Germany and his postdoctoral studies at Cornell University and UC Berkeley. He is Professor at University of Regensburg and at Cedars-Sinai Medical Center. His scientific merits are in the fields of replication and protein synthesis, platinum anticancer mechanisms, biochemistry of myxomycetes, polymer chemistry and drug delivery. He is frontier in the design of targeted nanodrugsand treatment of tumors in brain and breast. He has contributed over 150 scientific articles and book chapters. Presently he holds position at Nanomedicine Research Center at Neurosurgical Department of CSMC
image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version