alexa Polymorphism Of HFE Gene In Ischemic Heart Diseases And Its Relation With Iron Overload
ISSN: 2153-0769

Metabolomics:Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th International Conference and Exhibition on Metabolomics & Systems Biology
May 08-10, 2017 Singapore

Fadhil Jawad Al-Tuma, Zainab K Abeid and Karim O Al-Naffi
University of Kerbala, Iraq
Posters & Accepted Abstracts: Metabolomics
DOI: 10.4172/2153-0769-C1-038
Abstract
Background: Ischemic Heart Disease (IHD) burden consists of years of life lost worldwide. Diabetes mellitus is the major risk factor of coronary artery diseases; C282Y allele of HFE gene is significantly associated with iron overload (IO). To which extent HFE gene mutations and metabolic alterations contribute to the presence of atherogenic lipoprotein modifications happen in primary IO remains undetermined. Aim: Aim of the presented work was concerned to detect whether or not the C282Y and H63D mutations in the HFE gene might be associated with increased risk of ischemic heart diseases in obese patients and then to see their correlations with iron overload. Materials & Methods: This cross sectional study was conducted in Cardiac Care Unit at Al-Zahra Teaching Hospital, Karbala and Najaf Center for Heart Diseases during December 2015 to September 2016. It included 100 subjects (50 obese IHD patients and another 50 obese individuals as control group. Iron, total iron binding capacity (TIBC), ferritin, hs-Troponin I and lipid profile were determined. DNA was extracted from fresh blood by using Geneaid kit. PCR amplification by using specified primers and then Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP) and electrophoresis by using agarose gel (2%) with ethidium bromide was applied to detect the specific fragments. Results: The mean age of patient group was 58.06±10.22 (range 38-79 years) (30 male and 20 female). There is a significant difference between the allele frequencies of C282Y mutations in obese IHD patient groups as compared with obese controls (P<0.05). The relationships between the GA and GG genotypes in C282Y mutation in parameters: hs-Troponin I, lipid profile (total cholesterol, TG, LDL-C, HDL-C and VLDL-C), BMI, iron, TIBC and serum ferritin. The data observed no significant differences between the two groups (P>0.05) with all parameters except iron overload and hs-troponin I with C282Y mutation in patient groups. Conclusion: HFE gene polymorphism C282Y is associated with development of ischemic heart diseases. Iron, TIBC and ferritin are related with allele polymorphism C282Y mutation. The HFE mutations may act as genetic markers of IHD risk in Iraq population. There were significant elevations in serum lipid profile (total cholesterol, and LDL-cholesterol) in patients as compared with control group due to effect of IHD. Iron overload was elevated in IHD patients as compared with obese control group.
Biography

Email: f_altoma_56@yahoo.com

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords