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Positive Effects Of Sildenafil Therapy On Outcomes Of Congenital Heart Surgery | 50271
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

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Positive effects of sildenafil therapy on outcomes of congenital heart surgery

International Conference on Hypertension & Healthcare

Mohsen Sedighi

Iran University of Medical Science, Iran

Posters & Accepted Abstracts: J Clin Exp Cardiolog

DOI: 10.4172/2155-9880.C1.042

Most of Ventricular Septal Defects (VSDs) are complicated with Pulmonary Arterial Hypertension (PAH) which is the major cause of pulmonary hypertensive crisis and Right Ventricular Failure (RVF). We reviewed clinical outcomes of 63 infants who underwent cardiac surgery and were divided into three groups. Control group (n=20) did not receive sildenafil, while sildenafil A (n=22) received drug (0.3 mg/kg) before and after surgery. Sildenafil B (n=21) received drug at the initiation of surgery. Demographic data, preoperative and postoperative variables were compared among the patients. Patients in the sildenafil A had lower preoperative Pulmonary Arterial Pressure (PAP) compared to other groups (P=0.001). Patients in control group had longer cardiopulmonary bypass time (P=0.049). Also, postoperative PAP in patients of sildenafil A and B decreased significantly compared to control group (P=0.001). The intubation time and length of ICU stay were significantly longer in patients of control group compared to sildenafil A and B (P=0.001). Sildenafil therapy seems to be effective and safe to control PAH in children with CHD and has a positive impact on postoperative care.

Mohsen Sedighi is a PhD candidate of Neuroscience of Iran University of Medical Sciences. He is a young researcher at Isfahan Cardiovascular Research Center and member of Iranian Neuroscience Society. He has published several papers related to Congenital Heart Surgery in reputed journals and participated in several cardiovascular congresses.

Email: [email protected]