Positive Effects Of Sildenafil Therapy On Outcomes Of Congenital Heart Surgery | 50271
Journal of Clinical & Experimental Cardiology
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Most of Ventricular Septal Defects (VSDs) are complicated with Pulmonary Arterial Hypertension (PAH) which is the major
cause of pulmonary hypertensive crisis and Right Ventricular Failure (RVF). We reviewed clinical outcomes of 63 infants who
underwent cardiac surgery and were divided into three groups. Control group (n=20) did not receive sildenafil, while sildenafil A
(n=22) received drug (0.3 mg/kg) before and after surgery. Sildenafil B (n=21) received drug at the initiation of surgery. Demographic
data, preoperative and postoperative variables were compared among the patients. Patients in the sildenafil A had lower preoperative
Pulmonary Arterial Pressure (PAP) compared to other groups (P=0.001). Patients in control group had longer cardiopulmonary
bypass time (P=0.049). Also, postoperative PAP in patients of sildenafil A and B decreased significantly compared to control group
(P=0.001). The intubation time and length of ICU stay were significantly longer in patients of control group compared to sildenafil
A and B (P=0.001). Sildenafil therapy seems to be effective and safe to control PAH in children with CHD and has a positive impact
on postoperative care.
Mohsen Sedighi is a PhD candidate of Neuroscience of Iran University of Medical Sciences. He is a young researcher at Isfahan Cardiovascular Research Center and member of Iranian Neuroscience Society. He has published several papers related to Congenital Heart Surgery in reputed journals and participated in several cardiovascular congresses.