Background and Aims:
Hypertension is a common, multifactorial disorder, involving
large percentage of population in both developed and underdeveloped countries. Despite
intensive researches being carried out the world over, its cause cannot be ascertained in more
than 90% cases.
The aim of this study was to assess the correlation of adrenal hormones cortisol and aldosterone
with some known metabolic risk factors, affecting blood pressure and causing progression of
prehypertension stage into hypertension stage-1
Methods and Results:
276 subjects were recruited (aged 25 ? 65 years) in this casecontrol study,
classified into three categories; prehypertension (pre-HTN), hypertension (HTN) Stage I and
II, according to 7
JNC report and compared with age-matched normotensive control subjects.
Serum cortisol, aldosterone, electrolytes (sodium & potassium), total cholesterol, LDL and fasting blood glucose were estimated.
Height, weight, waist circumference, Systolic and diastolic blood pressures were recorded
Mean aldosterone level was within high normal range and statistically significant in HTN stage I & II. It had positive correlation
with total cholesterol and LDL in pre-HTN stage-I. The cortisol level was significantly correlated to BMI, Na
in control group,
& to BMI & WC in pre-HTN group, showing its association with obesity.
The sequence of pathophysiological processes leading to hypertension is suggested to be initiated by visceral
fat accumulation, in normotensive subjects. This is associated with dyslipidemia, hyperglycemia, salt sensitivity, secretion of
aldosterone, all leading to endothelial dysfunction, ultimately resulting in hypertension
Dr. Sadiqa Syed completed her MBBS from Dow Medical College, Karachi, Pakistan in the year 1985 and PhD in Physiology from University of
Karachi, Pakistan in the year 2011. Currently, working as Professor and Head of the Department of Physiology, Bahria University Medical and Dental
College, Karachi, since December 2008 till date. About 20 articles of her research were published and participated in many seminars in Pakistan
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