alexa Possible Neuroprotective Mechanisms Of Ginseng And Rutin In Experimental Model Of Head Injury Induced Cognitive Dysfunction
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

5th International Conference and Exhibition on Pharmacology and Ethnopharmacology
March 23-25, 2017 Orlando, USA

Anil Kumar, Hitesh Dhar and Puneet Rinwa
Panjab University, India
Posters & Accepted Abstracts: Clin Exp Pharmacol
DOI: 10.4172/2161-1459.C1.017
Abstract
Introduction: Head injury is a major cause of disability and death. Possible role of neuroinflammation, nitric oxide, microglia and oxidative stress have been suggested in the pathophysiology of traumatic brain injury related complications such as cognitive dysfunction. Objective: Therefore, the present study was designed to explore the possible role of ginseng and rutin and its interaction with nitric oxide modulator and microglial inhibitor against experimental of head injury induced behavioral, biochemical and molecular alterations. Materials & Methods: Wistar rats were exposed to head injury by using weight-drop method. Following injury and a post-injury rehabilitation period of two weeks, animals were administered vehicle/drugs for another two weeks. Results: Traumatic brain injury caused significant memory impairment in Morris water maze task as evident from increase in escape latency and total distance travelled to reach the hidden platform. Time spent in target quadrant and frequency of appearance in target quadrant was also significantly decreased in head trauma rats. Further, there was a significant increase in oxidative stress (elevated malondialdehyde, nitrite concentration and decreased reduced glutathione, superoxide dismutase and catalase levels), neuroinflammation (TNF-α and IL-6) and acetylcholinesterase levels in both cortex and hippocampal regions of traumatized rat brain. Ginseng (100-200 mg/kg), rutin (20-80) treatment for two weeks significantly attenuated all these behavioral, biochemical and molecular alterations, suggesting their neuroprotective effect. Further, combination of sub effective doses of ginseng (50 and 100 mg/kg) or rutin (40, 80) with microglia inhibitor as well as nitric oxide modulators significantly modulates their protective effect, respectively. The present study suggests that these flavonoids produce their neuroprotective effect by involving microglial as well as nitric oxide pathways. Conclusion: The study further provides a hope that these flavonoids could be used effectively for the management of brain traumatic injury and related complication.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords