Technical innovations, such as the high-throughput and highly efficient next-generation sequencing (NGS), hold the promise
for improving cancer management through better understanding of cancer biology and the discoveries of new biomarkers
significant for personalized oncology. However, how surgical pathology practice facilitates, collaborates with and nourishes from
the new process is a big challenge. Precision surgical pathology, defined by the speaker as a core and indispensable component of
personalized oncology, is a precise process that incorporates detailed gross denotations, bio-specimen repository, quality control,
histological and molecular classifications, oncogenomics, clinical-histological-molecular-genomic correlations, and oncological
epidemiology. Practicing precision surgical pathology in the setting of personalized oncology is able to identify putative,
diagnostic, therapeutically actionable, rarely occurring and unexpected bio-genomic markers that are clinically meaningful.
Selected cases of such a practice will be presented and discussed.
Hua Zhong is a practicing surgical Pathology and a member of the Cancer Institute of New Jersey
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