Preeclampsia And Its Associated Serum Markers | 50272
Journal of Clinical & Experimental Cardiology
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Objective: To determine the positive role of maternal hematological serum markers in gestation for preeclampsia.
Introduction: Preeclampsia affects 5% of all pregnancies and is a significant cause of maternal and neonatal morbidity and mortality.
Early risk stratification may improve the identification of women at highest risk for preeclampsia and provide an opportunity for
intervention. Studies have evaluated serum angiogenic markers in gestation for the commencement of preeclampsia.
Methods: Sample size was estimated by using the World Health Organization (W.H.O) software. Main clinical variables were
pregnancy associated plasma protein-A (PAPP-A) for aneuploidy screening, placental protein-13 (PP-13) for immune functions,
soluble fms-like tyrosine kinase-1 (sFlt-1) for placental ischemia, inhibin-A for down's syndrome and endoglin for vascular
permeability and hypertension were defined in reduced and full models of ANOVA. (Reduced model Y= β0 + β1X1 + ε and the full
model Y= β0+β1X1+ β2X2 + β3X3 + β4X4 + β5X5 + ε).
Results: Serum markers PAPP-A (OR 1.97; 95% (CI): 1.07-2.59), PP-13 (OR 2.76; 95% (CI): 2.07-3.59), sFlt-1 (OR 1.79; 95% (CI):
1.58-3.45), inhibin-A (OR 2.37; 95% (CI): 1.53-4.67) were statistically significant (p<0.001) and endoglin (OR 1.34; 95% (CI): 0.15-
2.59) was not significant( p>0.05). (Reduced model Y= β0 + β1PAPP-A + ε and the full model Y= β0 + β1PAPP-A + β2PP-13 + β3
sFlt-1 + β4 inhibin-A + β5 endoglin + ε). Serum PAPP-A and serum sFlt-1 showed a highly significant positive correlation (r=0.81;
p<0.001). Serum PAPP-A also showed a moderate correlation with PP-13 (r=0.62; p<0.01), inhibin-A (r=0.58; p<0.01).
Conclusion: Both, 1st trimester PAPP-A levels and sFlt-1 levels were notably lower in women who afterward developed preeclampsia.
Fizza Hassan is a student of Karachi Medical and Dental College. She is a medical student researcher and has contributed in a couple of papers in international medical journals. Her medical rotations include, Department of Medicine, Gynecology and Obstetrics, and Dermatology at Karachi Medical and Dental College, Abbasi Shaheed Hospital. During her electives she worked in outdoor patient department, wards, clinics and operation room. In the patient setting, she has worked with the medical team in caring for the needs of pregnant women and continued to care for them on the postpartum floor and also at the department of Medicine.