alexa Preferential Accumulation Of Gold Nanorods Into Skin Hair Follicles: Effect Of Nanoparticle Surface Chemistry
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

13th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology
July 24-25, 2017 | Rome, Italy

Nouf N Mahmoud
Alzaytoonah University, Jordan
Posters & Accepted Abstracts: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439-C1-050
Abstract
The accumulation of nanoparticles into specific targets in skin such as hair follicles has an advantage to treat many skin diseases with high efficiency and fewer side effects. The surface chemistry of nanoparticle is a major determinent to its interaction with biological systems. In this study, gold nanorods (GNR) functionalized with various surface ligands (hydrophilic polyethylene glycol capped-GNR (PEG-GNR); anionic polyacrylic acid capped-GNR (PAA-GNR); cationic PEGylated-cystamine capped-GNR (PEGCys- GNR); and hydrophobic polystyrene capped-GNR (PS-GNR)) were evaluated for their accumulation into hair follicles of human skin sheets using ex-vivo setup. The extent of GNR accumulation into hair follicles and other skin compartments was quantified by inductively coupled plasma–optical emission spectroscopy (ICP-OES) and their spatial distribution through skin layers was investigated by laser ablation-inductively coupled plasma-mass spectroscopy (LA-ICP-MS). Results revealed that the accumulation of GNR into hair follicles and skin compartments was highly dependent on the surface chemistry of the nanoparticles. The lipophilic properties of sebum-rich hair follicles enhanced the accumulation of hydrophobic PS-GNR into hair follicles (~13% of the total applied dose). On the other hand, neutral PEG-GNR were distributed into all skin compartments, especially the dermis (~11.5% of the total applied dose), which exhibits hydrophilic characteristics. Charged GNR showed negligible percent of penetration into any of skin compartments. The systematic study presented in this work may help to optimize GNR as promising approach for targeted skin diseases treatment and transdermal administration of drugs and therapy.
Biography

Email: nouf.mahmoud@zuj.edu.jo

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords