Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
P Sailaja Rao, Bala Tripura Sundari, K Sireesha and Prakash V Diwan
Sri Venkateshwara College of Pharmacy, India
Maratha Mandal Research Centre, India
Scientific Tracks Abstracts: Medicinal Plants
The objective of the present research work is to develop and characterize an ethosomal gel from methanolic leaf extract of Mangifera indica and evaluating the same for wound healing activity. There are many reports revealing the pharmacological activity of the herbal extract but only few were reported as suitable dosage form. Different formulations of three doses (100 mg, 200 mg, 300 mg) of ethosomes using lecithin, cholesterol and ethanol were prepared from Mangifera indica herbal leaf extract. The entrapment efficiency of ethosomes was 65.1% to 96.54% and average vesicle size was 926 nm. Based on the entrapment efficiency and drug release further incorporation into gel formulations was done using carbopol 940. Wound healing activity was evaluated by excision wound healing model for the three formulations using rats as experimental animals. Animals are divided into 5 groups (n=6) and silver nitrate was used as standard. The percentage wound area, wound area and period of epithelialization were determined. The pH of the gel formulations was found to be in the range of 5.4-6.2 with drug content of 50.47%-83.53%. In the wound healing activity, the wound healing effect was studies for a period of 21 days and the treated (200 mg) animals showed significant reduction in percentage wound area, wound area and period of epithelialization. The order of wound healing efficacy of test formulations was found to be 200 mg/kg >100 mg/kg >300 mg/kg >standard. The present study revealed that ethosomal gel applied topically possess wound healing activity.
P Sailaja Rao is a Pharmacologist, obtained her PhD degree in Pharmaceutical Sciences from Jawaharlal Nehru Technological University Hyderabad, India. Presently, she is working as an Associate Professor in reputed pharmacy college and has 15 years of experience in teaching and research. She has 10 research publications in national and international journals of repute to her credit. Her areas of interests are diabetes, drug-drug interactions and she has made significant contribution in herbal medicines.