alexa Presence Of Human Parvovirus B19 Genomic Sequence In Tissue DNA Of Post-mortem Individuals With Unspecified Encephalopathy | OMICS International
ISSN: 2161-0517

Virology & Mycology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

9th International Virology Congress and Expo
March 13-14, 2017 London, UK

Anda Vilmane
Riga Stradins University, Latvia
Posters & Accepted Abstracts: Virol Mycol
DOI: 10.4172/2161-0517.C1.018
Abstract
Encephalopathy is a syndrome characterized by a global brain dysfunction. It can have different causes, including viral infections, but in many cases the aetiology and pathogenesis remain unclear. Human parvovirus B19 (B19) belonging to Parvoviridae family, Parvovirinae subfamily and Erythroparvovirus genus is considered as clinically important pathogen in different diseases, but data on B19 association with a variety of neurological manifestations is ambiguous. The aim of this study was to determine the frequency of B19 genomic sequence in tissue DNA of individuals (post-mortem) with unspecified encephalopathy (UEP). Autopsy brain tissue (frontal lobe and temporal lobe) and peripheral blood samples from 19 individuals with UEP were included in this study. DNA from tissue and peripheral blood samples was extracted using phenol-chloroform method, presence of B19 NS1 genomic sequence in DNA samples was determined using nested PCR (nPCR). B19 NS1 genomic sequence was detected in 8 out of 19 (42.1%) individuals with UEP. In two individuals with UEP viral genomic sequence was detected in all three sample types (peripheral blood, frontal and temporal lobe tissue), in two individuals - two different sample types (one in blood and temporal lobe and other in brain tissue) and in four individuals just in one of DNA sample types (one in blood and three in brain tissue). Obtained results showed that B19 genomic sequence is present in tissue DNA of individuals with UEP, therefore further research is carried out by increasing study cohort and determining viral load, and antigen expression in UEP comparing to control group.
Biography

Anda Vilmane has done her Master’s in Biology and is a Research Assistant at August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia. She is a first year PhD student at Riga Stradins University and her PhD thesis is about human parvoviruses B19 and human bocavirus involvement in inflammatory neurological diseases.

Email: anda.vilmane@rsu.lv

image PDF   |   image HTML
 

Relevant Topics

OMICS International Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version