Probing Toxicologically Relevant Interactions Of Inorganic Pollutants In The Bloodstream | 50735
Journal of Environmental & Analytical Toxicology
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Numerous bio-monitoring studies have revealed that various human populations including children are exposed to environmentally
abundant non-essential metals/metalloid species (e.g. cadmium, lead, mercury and arsenic). It is unclear; however, if the chronic
low level exposure of humans to certain non-essential metals/metalloid species may be linked to the etiology of human diseases. Since
health care costs that are related to chronic human diseases are increasing, the establishment of functional connections between the
exposure to non-essential metals/metalloid species and human diseases is viewed by many as one of the greatest challenges in the
post-genomic era. Uncovering the underlying biochemical mechanisms, however, represents a truly monumental task. Conceptually,
this quest requires fundamental advances in two particular areas, namely a better understanding of the biochemical fate of nonessential
metals/metalloid species in the bloodstream and within toxicological target organs. Our general lack of understanding
toxicologically relevant interactions of non-essential metals/metalloid species in the bloodstream must be attributed to its inherent
complexity on the one hand and a general lack of appropriate instrumental analytical methodologies on the other. To this end,
we develop and apply new analytical methods to probe toxicologically critical interactions between non-essential metal/metalloid
species and blood constituents based on liquid chromatography. After a brief overview of the instrumental analytical methods that
we have developed to probe these interactions either in a ‘bottom-up’ or a ‘top-down’ manner, some recent results will be highlighted.
Jürgen Gailer received his PhD from Karl-Franzens Universität Graz/Austria in 1997 and then completed postdoctoral studies at the University of Arizona (Tuscson/US; Erwin Schrödinger fellow) and the GSF National Research Center for Environment and Health (Munich/Germany; Alexander von Humblodt fellow). In 2002 he joined Boehringer Ingelheim Austria (Biopharmaceutical Production) where he was team leader for the downstream processing. He joined the Department of Chemistry/University of Calgary in 2004 where he currently is an Associate Professor and has a co-appointment in the Environmental Science Program.