alexa Pro-carcinogenic Action Of Beta-carotene
ISSN: 2161-0932

Gynecology & Obstetrics
Open Access

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3rd Annual Conference on Gynecologic Oncology & Preventive Oncology
July 20-21, 2017 Chicago, USA

Homer S Black
Baylor College of Medicine, USA
ScientificTracks Abstracts: Gynecol Obstet (Sunnyvale)
DOI: 10.4172/2161-0932-C1-015
Abstract
Over 600 carotenoids have thus far been identified. About 100 are found in foods consumed by humans. Beta-carotene, as a pre-cursor of vitamin A, can have a profound influence on human health. An epidemiological study in 1981 found that those persons, who consumed foods rich in carotenoids such as green leafy and yellow vegetables were at lower risk for cancer. Beginning in the late 70s, a series of experimental UV-carcinogenesis studies found beta-carotene to be photoprotective. The role of beta-carotene as an anti-cancer agent began to be questioned as a result of intervention studies in which the incidence of non-melanoma skin cancer was unchanged in patients receiving beta-carotene supplements (1990) and in betacarotene supplemented smokers who suffered a significant increase in lung cancer occurrence (1996). This was followed by an experimental study (1998) in which beta-carotene supplementation was shown to exacerbate UV-carcinogenic expression. The differences in response to beta-carotene supplementation were ascribed to type of diet, either closed-formula or semi-defined. A controlled dietary study was conducted in which varying levels of vitamin C and E was fed to animals receiving control and beta-carotene supplemented semi-defined diets. Vitamin C level had no effect on repair of the presumed caroteinoid radical cation. Beta-carotene supplementation resulted in a three-fold increase in tumor multiplicity. However, when the dietary level of vitamin E was reduced, a nearly six-fold increase in tumor multiplicity, compared to control, occurred. The mechanism of beta-carotene exacerbation of UV-carcinogenesis remains speculative but beta-carotene supplementation should not be recommended as a cancer prevention strategy for the general population.
Biography

Homer S Black has completed high school at Nederland, Texas in 1952 and entered Texas A&M University and completed BSc in Animal Science. He has attended Sam Houston State University where he received MEd and then attended LSU where he earned his PhD in Plant Biochemistry. He has later received MSA in Business/Health Science Management from the University of Houston, USA. He has joined the Baylor Faculty and Veterans Medical Center in 1968. His research centered on UVR-induced skin cancer and antioxidant and dietary lipid modulation of this cancer. He was retired in 2003 and became Professor Emeritus at Baylor College of Medicine.

Email: [email protected]

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