alexa Production Of Nano-dendrimer Containing HPV E 16d Candidate Vaccine And Evaluation Of Its Immune Responses In Laboratory Murine Model
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference on Vaccines & Vaccination
July 29-31, 2013 Embassy Suites Las Vegas, NV, USA

Atefeh Shahbazi
Accepted Abstracts: J Vaccines Vaccin
DOI: 10.4172/2157-7560.S1.018
Abstract
C ervical cancer is the second most common cancer in women worldwide. More than 99% of cervical cancers contain human papillomavirus (HPV) and HPV type 16 is the most common type in all countries. Papillomavirus-induced carcinogenesis is mainly related to two proteins E6 and E7 that are consistently expressed in HPV positive cervical carcinomas and are considered substantially for therapeutic implications. Although the size of these proteins is small, they can attach to the regulatory proteins in host cells, eliminate cell-mediated immunity, and causes malignancy in the target tissue. Up to now, different methods have been used for production of therapeutic vaccines against human papillomavirus. These vaccines have some advantages and disadvantages. Today, researchers are seeking for carriers that can be loaded with vaccines and enhance the therapeutic effectiveness of the vaccine, so they have gone into production of dendrimers and nanotechnology. Due to their interesting abilities for carrying DNA, passing through the membrane and their appropriate size, dendrimers have been used extensively in vaccine delivery. In terms of size, shape, length and functional surface groups, nano-dendrimers are very similar. They can place the molecules among their branches and protect them against external factors and release them in target tissues. In this study, nano-dendrimer based E7d protein as a vaccine candidate was made and then at the dose of 10mg was administered to the experimental groups. Two groups were vaccinated with Ed proteins; frond and alum adjutant and controls were injected with PBS buffer and dendrimer. Mice were vaccinated subcutaneously three times at two weeks interval. Two weeks after the last injection the immune responses were evaluated. Lymphocyte proliferative responses by BrdU method and the cytokines IL-4, IFN-g, and total antibody IgG1, IgG2a were evaluated with ELISA. Finally, the results are shown that dendrimer nano vaccine candidate based on E7d - protein provoke the cellular and humeral immune responses and could be a good candidate for study in humans. Keywords: Human papillomavirus, E7d protein.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]line.com

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords