alexa Production Of Polymer Nano Fiber By Electro Spinning For The Enhancement Of Drug Release Rate
ISSN: 2169-0316

Industrial Engineering & Management
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

International Summit on Industrial Engineering
December 08-10, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Tibebe Yibgeta Fente
Posters: Ind Eng Manage
DOI: 10.4172/2169-0316.S1.005
Drug delivery method is one of the techniques that enable us the introduction of therapeutic agent in the human body. It can improve its efficiency by controlling the rate, the time and the site of release. Currently, due to the use of nano fiber which facilitates the delivery of sufficient amount of drugs for a certain time, avoids the degradation of non released drugs and eliminate the non uniform concentration of drugs during release many researchers have attracted by the sector including me. Based on this, for the lab scale production of polymer nano fiber, a biodegradable polymer Poly lactic acid (PDLLA) was used and for the encapsulation as an agent Albumin was used as a model drug during the lab investigation. By using electro spinning techniques, which is the production of filaments by electrostatic force, the nano fibers were produced by varying different parameters such as: flow rate, composition and voltage. Since the dispersion of drug is uniform and the drug released readily, emulsion technique was employed for the encapsulation of the drug in the polymer. The solvent used to dissolve both the drug and the polymer were Dichloromethyl, n- n-Dimethyl formamide and methanol-water mixture with the ratio of 5:3:2 respectively. Hence, the produced fibers were analyzed by Optical, Scanning electron microscope (SEM) and Co focal microscope. Consequently, the optimum product obtained for the delivery of Albumin (0.5%) was having a polymer concentration of 9%, voltage of 22KV and flow rate of 0.4ml/hr. Frankly, the optimum product has better fiber thickness and the drug has distributed uniformly in the fiber. Since there was a homogenous distribution of drug in the fiber the drug was released by diffusion within a short period of time than the conventional drug release techniques and the fast degradation of PDLLA nano fibers was also speed up the release rate.
Tibebe Yibgeta Fente is a Material Science and Engineering master?s student in Trento University, Italy. I did my Bsc by Chemical Engineering in Addis Ababa University Institute of Technology on July 2011 and I was an assistance lecturer in Bahir Dar University since September 2011- 2012.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version