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Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and
physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the
multigenic trait ?anxiety?. We used microarrays to investigate the gene expression profiles of different brain regions within the
limbic system of mice which were selectively bred for either high (HAB) or low (LAB) anxiety-related behavior, and also show
signs of comorbid depression-like behavior.
We identified and confirmed sex-independent differences in the basal expression of 13 candidate genes, using tissue from the
entire brain, including coronin 7
, cathepsin B
, muscleblind-like 1
carrier family 25 member 17
tribbles homolog 2
inc finger protein 672
binding cassette, sub-family A member 2
ectonucleotide pyrophosphatase/phosphodiesterase 5
group nucleosomal binding domain 3
and pyruvate dehydrogenase beta
. Additionally, we confirmed brain
region-specific differences in the expression of synaptotagmin 4
Our identification of about 90 polymorphisms in
suggested that this gene might play a critical role in shaping our mouse
model?s behavioral endophenotypes. Indeed, the assessment of anxiety-related and depression-like behaviors of
mice revealed an increase in depression-like behavior in females.
Altogether, our results suggest that
has significant effects on emotionality, irrespective of the tested mouse strain, making
it a promising target for future pharmacotherapy.
Ludwig Czibere has completed his Ph.D in biology 2009 at the Ludwig Maximilians University in Munich, and has further conducted his postdoctoral
studies at the Max Planck Institute of Psychiatry, first as a Max Planck postdoctoral fellow, then as a postdoctoral scientist. His research is focused
on neurogenomics and neurotranscriptomics of anxiety- and depression-like disorders. He published about 8 papers and was awarded the Ernst and
Berta Scharrer Prize of the German Society of Endocrinology (DGE) in 2009.
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