alexa Prognostic Significance Of Two Dimensional Agnor Evaluation In Local Advanced Rectal Cancer With Treated Chemo Radiotherapy
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th World Congress on Cancer Science & Therapy
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Nalan Imamoglu, Mete Gundog, Oguz G Yildiz, Dicle Aslan, Isin Soyuer and Serdar Soyuer
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.033
Abstract
The aim of this study is to reveal the prognostic importance of Argilophilic Nucleolus Organizer Region (AgNOR) proteins on the patients with stage II-III rectal cancer with chemoradiotherapy. Silver staining technic was applied to the 3 μm section collected from the parafin blocked tissues on 30 rectal cancer patients who treated with 5-FU based chemotherapy and 50, 4 Gy (1,8 Gy/day, 28 fractions) external beam radiotherapy to the pelvic lymph nodes and tumor bed, between May 2003 ? June 2006 at University of Erciyes, M.K. Dedeman Oncolgy Hospital. The microscopic displays of the cells were transferred in to the computer medium via video camera. AgNOR area/Total Nucleus area (NORa/TNa) values were found. The facts are analysed in terms of locoregional recurrence (LRR), disease free survival (DFS) and overall survival (OS). The statistical analysis was accomplished by SPSS 15.0 package programme. OS and DFS in the high NORa/TNa (>9.02) patients were 52.21 months and 39.41 months, respectively. OS and DFS in the low NORa/TNa (<9.02) patients were 100.69 mounths and 98.38 mounths, respectively. A statistically significant difference was found between high NORa/TNa patients and low NORa/TNa patients (p=0.001) and the prognosis in the high NORa/TNa patients was worse (p<0.05). In terms of OS and DFS, a statistically significant negative correlation was found with value of NORa/TNa in the correlations tests (p=0.001). Additionally, there was a statistically significant correlation found between NORa/TNa and LRR (p=0.020). As a result, we suggested that two-dimensional AgNOR evaluation may be a safe and usable parameter for prognosis and indicator of cell proliferation instead of AgNOR dots.
Biography
Nalan Imamoglu has completed her PhD from Erciyes University, Medical Faculty, Department of Medical Biology in Turkey. Her present occupation is Assoc. Prof. Dr. Her scientific interests are cytogenetics, tumour/cancer biology and genetics and genotoxicity. She is a member of Society of Medical Biology and Genetics and Society of Medical Genetics. She has published about 20 papers in reputed journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords