alexa Prospective Dosimetric And Comparative Study Evaluating Two Dimensional Vs. Three Dimensional Planning In Patients With Cervical Cancer Undergoing High Dose Rate Brachytherapy
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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14th World Cancer & Anti-Cancer Therapy Convention
November 21-23, 2016 Dubai, UAE

Irfan Bashir
Batra Hospital and Medical Research Centre, India
Posters & Accepted Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.C1.094
Abstract
We did a prospective dosimetric and comparative study of 2D radiography and computed tomography (CT) based three dimensional planning (3D) in patients with carcinoma cervix undergoing high dose rate brachytherapy. A total of 16 patients underwent 48 sessions of brachytherapy after receiving external beam radiotherapy to a dose of 50.4 Gy in 28 fractions. Brachytherapy was planned to a dose of 7 Gy to point A in each session, to a total of 3 sessions for each patient. For 2D planning, doses to point A and ICRU bladder and rectal points were recorded. For 3D planning, doses received by 90%, 95% and 100% of the target volume as well as doses to 0.1 cc, 1 cc, 2 cc and 5 cc of bladder and rectum were recorded. For a prescription of 7 Gy to point A, mean dose received by 90%, 95% and 100% of the target volume was 5.9 Gy, 5.7 Gy and 5.3 Gy respectively. Mean dose to ICRU bladder point was 2.92 Gy while as doses to 0.1 cc, 1 cc, 2 cc and 5 cc of bladder were 7.2 Gy, 6.3 Gy, 5.7 Gy and 5.2 Gy respectively. Mean dose to ICRU rectal point was 3.68 Gy while as doses to 0.1 cc, 1 cc, 2 cc and 5 cc of rectum were 6.8 Gy, 5.7 Gy, 5.1 Gy and 4.5 Gy respectively. We concluded that 2D brachytherapy overestimates the target coverage and underestimates the doses to OARs. Wherever feasible, 3D brachytherapy should be encouraged as it allows precise identification and dose optimization of target volume and OARs.
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