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Protection Against Oral Mucositis In Patients Undergoing Radiotherapy Of The Head And Neck With Topical Mucoadhesive Gel Containing Propolis | 60868
ISSN: 2471-8556

Oncology & Cancer Case Reports
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Protection against oral mucositis in patients undergoing radiotherapy of the head and neck with topical mucoadhesive gel containing Propolis


Vagner Rodrigues Santos, Vladimir R.A.S. Noronha, Henrique C. Meira, Ruan S. Silva, Mariana T. Rodrigues, Luis Guilherme V. Madeira, Mayara F. Paiva and Barbara F. G. Queiroz

Universidade Federal de Minas Gerais, Brazil

ScientificTracks Abstracts: Oncol Cancer Case Rep

DOI: 10.4172/2471-8556.C1.002

The objective of this phase II study was to determine the effectiveness of a mucoadhesive propolis gel in the prevention of radiation-induced oral mucositis. Thirty-four patients who were selected to undergo radiation therapy for oral cancer were included in this open-label trial. They were advised to use a mucoadhesive gel containing propolis 5,0% w/v three times a day starting one day before the course of radiation therapy and concluding after 2 weeks of radiation therapy. A weekly follow-up for evaluation of food intake, pain and grading of mucositis was performed. In order to confirm the absence of Candida-related mucositis in patients who developed mucositis, it was performed exfoliative cytology of buccal mucosa, palate and tongue and the material for Candifast() Candida species identification. At the end of the study was made the compliance of patients, quality, appreciation and acceptance of product evaluation. Twenty patients did not develop mucositis, two patients developed grade 1 mucositis and two patients developed grade 2 mucositis. None of the patients discontinued food intake and no pain was observed during the study. Candidosis was not detected in any patient. Mucoadhesive propolis gel could be considered as a potential topical medication for preventing radiation-induced oral mucositis. Acnowledgements: FAPEMIG/CNPq/ CENEX-FOUFMG/PROEX-UFMG.

Vagner Rodrigues Santos is Graduate in Dentistry, Associate Professor at School of Dentistry of the Minas Gerais Federal University(SD/UFMG). He has PhD in Oral Pathology (Faculty of Medicine/UFMG), Master in Microbiology(INRA–France), and Post-doctor in Natural Products at University of California Berkeley, USA. He is coordinator of Dentistry Care Clinic to Irradiated in head and neck Patients. Participates in the post-graduate program , guides doctoral, master’s and undergraduate research students. Search developing new drugs based on propolis and medicinal plants for prevention and treatment of oral lesions. He has 50 published papers with 387 citations by ResearchGate.

Email: [email protected]

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