Protective And Restorative Effects Of Melatonin And Coenzyme Q Against Propionic Acidinduced Biochemical Autistic Features In Rat Pups | 11100
Journal of Clinical Toxicology
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Exposures to environmental toxins are now thought to contribute to the development of autism as a
neurodevelopmental disorder. Results from animal studies may guide investigations of human populations toward identifying
environmental contaminants and drugs that produce or protect from neurotoxicity and may help in the treatment of
neurodevelopmental disorders like autism.
To study the protective and restorative effects of melatonin and coenzyme Q on brain intoxication induced by
propionic acid (PPA) in rats.
48 young male western albino rats were enrolled in the present study. They were grouped into six equal groups each of 8
rats. First group received a nuerotoxic dose (250 mg/kg body weight/day for 3 days) of buffered PPA. The second group consisted
of rats to which only phosphate buffered saline was administered and was used as a control group. The third and fourth groups
were treated with coenzyme Q (4.5 mg/kg body weight) or melatonin (10mg/kg body weight) for one week after being intoxicated
with the PPA as described above (therapeutically treated groups). Fifth and sixth groups were treated with either coenzyme Q
or melatonin for one week followed by PPA intoxication (protected groups). Gamma amino-buteric acid (GABA), serotonin,
dopamine, interferon γ-inducible protein 16 and oxytocin together with comet DNA assay were measured in brain tissues of the
six studied groups.
The obtained data showed that PPA caused multiple signs of brain toxicity as measured by depletion of GABA, serotonin,
and dopamine as three important neurotransmitters that reflect brain function, interferon γ-inducible protein 16 and oxytocin. A
high significant increase of tail length, tail DNA % damage and tail moment as three comet DNA assay parameters were reported
as genotoxic effect of PPA. Melatonin and coenzyme Q showed protective and restorative effects on PPA - induced changes in rats
as there was a remarkable amelioration of most of the measured parameters.
In conclusion, melatonin and coenzyme Q, as confirmed by biochemical assays and DNA double strand breaks
markers, has potential protective and restorative effects against PPA-induced brain injury
Afaf El-Ansary is a Biochemist, graduated from Biochemistry department, Ain Shams University, Egypt in 1974. She worked in the National
Research Centre, Egypt from 1976-2000. Since 2001, she is working in Biochemistry Department, King Saud University, KSA. She has published
more than 45 papers related to metabolic integration between schistosome parasite and molluscan hosts. She recorded a patent on the "use of
sublethal concentration of
plant for the control of schistosomiasis". She was recognized by the Marquis Who's Who in science and
engineering, Eight's edition, 2005-2006. She is member in number of national and international societies and she is recorded as reviewer in many
international journals. In recent years, she focused on the screening of biochemical markers related to autism and she got about 40 published papers
in high impact factor journals
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