alexa Protective Effect Of 6-Gingerol Against Oxidative Stress Induced By Zearalenone And Its Metabolites | 9362
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

International Conference on Integrative Biology Summit
August 05-07, 2013 Embassy Suites Las Vegas, NV, USA

Intidhar Ben Salem, Salwa Abid-Essefi, Christophe Lemaire and Hassen Bacha
Accepted Abstracts: J Comput Sci Syst Biol
DOI: 10.4172/0974-7230.S1.004
Abstract
Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin produced by several species of Fusarium in cereals and agricultural products. ZEN and its metabolites: α -Zearalenol (α-Zol) and β-Zearalenol ( β -Zol) have been implicated in several mycotoxicosis in farm animals and in humans. Several reports suggest that oxidative damage seems to be a key determinant of ZEN and its metabolites induced toxicity in vitro and in vivo. The aim of the current study was to evaluate the protective effects of 6-Gingerol (6-Ging), against ZEN and its metabolites induced cytotoxicity, reactive oxygen species (ROS) and mitochondrial superoxide anion O 2 .- generation, loss of the mitochondrial transmembrane potential ( ∆ψ m ), lipid peroxidation (MDA), DNA fragmentation and also against ZEN-induced endoplasmic reticulum (ER) stress in cultured HCT-116 cells. Indeed, cytotoxicity effects were studied using MTT viability assay and flow cytometry analysis, ROS generation and MDA formation measurement. To check whether the oxidative stress induction was associated to DNA lesions, we looked for DNA fragmentation using Comet test. Besides, the implication of ZEN and its metabolites on ER stress and then on the activation of the unfolded protein response (UPR) was demonstrated by Western blot analysis. Our results indicated that ZEN, α-Zol and β -Zol induced several toxic effects and significant alterations mediated by oxidative stress mechanism. Treatment by ZEN/metabolites combined to the lowest dose of 6-Ging (5 μM) showed a significant reduction of ZEN induced damages for all tested markers and a noticeable reduction of DNA fragmentation. It could be concluded that 6-Ging is effective in the protection against ZEN hazards. This could be relevant, particularly with the emergent demand for natural products which may counteract the detrimental toxic effects mediated by oxidative stress process and therefore prevents multiple human diseases. in
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]online.com

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version