alexa Protective Effect Of Perilla Oil And Alpha-linolenic Acid On Neuronal Apoptosis Induced By Oxidative Stress
ISSN: 2161-0509

Journal of Nutritional Disorders & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

JOINT EVENT: 13th International Congress on Advances in Natural Medicines Nutraceuticals & Neurocognition & 14th International Conference on Clinical Nutrition
July 27-29, 2017 Rome, Italy

Ah Young Lee, Hyun Young Kim, Sanghyun Lee, Myoung Hee Lee and Eun Ju Cho
Pusan National University, Republic of Korea
Gyeongnam National University of Science and Technology, Republic of Korea
Chung-Ang University, Republic of Korea
National institute of Crop Science - Rural Development Administration, Republic of Korea
Posters & Accepted Abstracts: J Nutr Disorders Ther
DOI: 10.4172/2161-0509-C1-007
Abstract
Oxidative stress plays a key role in neuronal cell damage, which is associated with neurodegenerative disease. Recently, attention has been paid to searching for natural source that can protect neuronal cell damage against oxidative stress. Although there are evidences that dietary n-3 fatty acid has beneficial effects, it has been focused on fish oil. Alphalinolenic acid (ALA) is also promising n-3 fatty acids in vegetable oils with health beneficial roles. Perilla oil (PO) contains the largest proportion of ALA. However, the study on molecular mechanism between ALA and hydrogen peroxide (H2O2)- induced neuronal apoptosis has not been studied yet. The aim of present study is to investigate the neuro-protective effects of PO and ALA against H2O2-induced oxidative stress in SH-SY5Y neuronal cells. Our result showed that treatment with PO and ALA significantly attenuated H2O2-induced cell death, indicating that PO and ALA potently blocks H2O2- induced neuronal apoptosis. Furthermore, cleaved-poly ADP ribose polymerase, cleaved caspase-3 and -9 activations were decreased in the presence of PO and ALA and H2O2-mediated down-regulated Bax/Bcl-2 ratio was blocked after treatment with PO and ALA. Taken together, the protective role of PO from neuronal cell damage is mainly attributed to ALA. The present study suggests that PO and ALA may play potent therapeutic agents for neurodegenerative disorders such as Alzheimer’s disease.
Biography

Ah Young Lee is a PhD candidate in Food Science and Nutrition at Pusan National University of Korea, and conducts study under the guidance of Professor Eun Ju Cho. Her research activities include Bioavailability of Natural Sources in vitro and in vivo system. She has authored or co-authored 18 manuscripts, and is a fellow funded by Global PhD Fellowship from National Research Foundation. Her laboratory mainly conducts research on development of nutraceuticals with cognitive improvement using natural sources, and currently interests in mechanisms of amyloid beta metabolism that helps explain neurodegenerative disease such as Alzheimer’s disease.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords