Protective effect of the standardized extract of Holmskioldia sanguinea on tumor bearing mice

6^th World Congress on Medicinal Chemistry and Drug Design

June 07-08, 2017 Milan, Italy

Mahesh Pal, Tripti Mishra, Ch V Rao and D K Upreti

CSIR - National Botanical Research Institute, India

Posters & Accepted Abstracts: Med Chem (Los Angeles)

Abstract :

Cancer has been considered to be very dreadful disease. Holmskioldia sanguinea is a large climbing shrub found in the Himalayas at an altitude of 5,000 feet and preliminary investigation showed the excellent yield of andrographolide and subjected for the anticancer activity. Protective effect of Holmskioldia sanguinea leaf ethanolic extract has been investigated against Ehrlich ascites carcinoma (EAC) and Dalton�s ascites lymphoma (DAL) in Swiss albino mice and to evaluate the possible mechanism of action. The enzymatic antioxidant status was studied on tumor bearing mice, which shows the potential of the compound to possess significant free radical scavenging property and revealed significant tumor regression and prolonged survival time. The isolated bioactive molecule andrographolide from Holmskioldia sanguinea yields 2.5% in subject to HPTLC/HPLC analysis. The cellular defense system constituting the superoxide dismutase, catalysis was enhanced whereby the lipid peroxidation content was restricted to a larger extent. The Holmskioldia sanguinea is a new source of andrographolide and demonstrated the potency in treatment of cancer.

Biography :

Email: drmpal.nbri@rediffmail.com