alexa Protective Effective Of Curcumin On Cyclophasphomide Induced Chromosomal Aberrations In Germ Cells Of Mice | 22722
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

4th World Congress on Cancer Science & Therapy
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Yadamma K and Rudrama Devi K
Accepted Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.035
Abstract
Herbs are gaining additional focus because of their less toxicity and high efficacy against a number of ailments. Epidemiological studies have shown that fruits, vegetables, spice, and medicinal herbs are rich in antioxidants and other micronutrients that protect against diverse forms of chemically induced carcinogenesis, inhibit DNA damage, mutagenesis and lipid peroxidation. Cyclophosphamide (CP) is an anti?cancer alkylating agent. The metabolites of this compound can alkylate nucleophilic sites in DNA, RNA and protein. It induces DNA single strand breaks at molecular level in rat embryos in testicular cells. Further Cyclophosphamide is capable of inducing structural chromosomal aberrations in Chinese Hamster cells, in human chorionic villi and various stages of spermatogenesis in germ cells. Curcumin is a yellow pigment commonly used as a spice and food coloring agent is procured from rhizomes of Curcumin longa and is a major chemo preventive compound of turmeric. In the present study, the anti mutagenic potential by curcumin has been evaluated using in in vivo assay in meiotic cells of male mice. Curcumin was given in 10, 15 and 20 mg/kg body wt, and assayed for chromosomal aberrations individually in the first set of experiment. The animals were maintained for 60 days and mice were scarified and meiotic preparations were made, stained with Giemsa stain according to the procedure of Evans et al., 1964. In the second set of experiment curcumin was given a dose of 10, 15 and 20 mg/kg body wt, of curcumin for seven consecutive days prior to CP treatment 50mg/kg body wt, a significant induction of chromosomal aberrations were observed in germ cells of mice. However in curcumin supplemented animals no significant induction in chromosomal damage was recorded. In different curcumin supplemented groups, a dose dependent significant decrease in cp induced clastogenicity was recorded when compared to CP treated group. The incidence of aberrant cells was found to be reduced by three doses of curcumin. The obtained results clearly revealed the antigenotoxic potential of cucumin against CP induced chromosomal mutations in germ cells of mice.
Biography
Yadamma K has completed her PhD in Osmania University, Hyderabad. Presently she is working as a Senior Technical Officer in NCLAS, at National Institute of Nutrition (NIN). Govt. of India, ICMR, New Delhi. She has successfully published two articles in international journals and presented various articles at national and international conferences.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version