Protective Effective Of Curcumin On Cyclophasphomide Induced Chromosomal Aberrations In Germ Cells Of Mice | 22722
Journal of Cancer Science & Therapy
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Herbs are gaining additional focus because of their less toxicity and high efficacy against a number of ailments.
Epidemiological studies have shown that fruits, vegetables, spice, and medicinal herbs are rich in antioxidants and other
micronutrients that protect against diverse forms of chemically induced carcinogenesis, inhibit DNA damage, mutagenesis and
lipid peroxidation. Cyclophosphamide (CP) is an anti?cancer alkylating agent. The metabolites of this compound can alkylate
nucleophilic sites in DNA, RNA and protein. It induces DNA single strand breaks at molecular level in rat embryos in testicular
cells. Further Cyclophosphamide is capable of inducing structural chromosomal aberrations in Chinese Hamster cells, in
human chorionic villi and various stages of spermatogenesis in germ cells. Curcumin is a yellow pigment commonly used as
a spice and food coloring agent is procured from rhizomes of Curcumin longa and is a major chemo preventive compound of
turmeric. In the present study, the anti mutagenic potential by curcumin has been evaluated using in in vivo assay in meiotic
cells of male mice. Curcumin was given in 10, 15 and 20 mg/kg body wt, and assayed for chromosomal aberrations individually
in the first set of experiment. The animals were maintained for 60 days and mice were scarified and meiotic preparations were
made, stained with Giemsa stain according to the procedure of Evans et al., 1964. In the second set of experiment curcumin
was given a dose of 10, 15 and 20 mg/kg body wt, of curcumin for seven consecutive days prior to CP treatment 50mg/kg
body wt, a significant induction of chromosomal aberrations were observed in germ cells of mice. However in curcumin
supplemented animals no significant induction in chromosomal damage was recorded. In different curcumin supplemented
groups, a dose dependent significant decrease in cp induced clastogenicity was recorded when compared to CP treated group.
The incidence of aberrant cells was found to be reduced by three doses of curcumin. The obtained results clearly revealed the
antigenotoxic potential of cucumin against CP induced chromosomal mutations in germ cells of mice.
Yadamma K has completed her PhD in Osmania University, Hyderabad. Presently she is working as a Senior Technical Officer in NCLAS, at National Institute of
Nutrition (NIN). Govt. of India, ICMR, New Delhi. She has successfully published two articles in international journals and presented various articles at national and
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