Li Li
Capital Medical University, China
Posters & Accepted Abstracts: Neurochem Neuropharm
Oxymatrine, a quinolizidine natural drug extracted from Sophora japonica, has been reported to have neuroprotective effect and cardioprotective effect. However, the protective effect of oxymatrine on arsenic trioxide (As2O3)-induced liver injury has not been reported. In the present study, we investigated the protective effects of oxymatrine on As2O3-induced liver injury in rats. Male Wistar rats were administrated with 3 mg As2O3 intravenously on alternate days for 4 days. Oxymatrine was given 1 h before As2O3 treatment. The results showed that oxymatrine inhibited As2O3-induced hepatic pathological damage, liver ROS level and MDA level. As2O3 decreased the antioxidant enzymes SOD, GPX, and CAT activity; and the decrease was inhibited by treatment of oxymatrine. Furthermore, oxymatrine attenuated the retention of arsenic in liver tissues and improved the expression of Nrf2 and HO-1. In conclusion, our results suggested that oxymatrine protected against As2O3- induced oxidative damage by activating Nrf2/HO-1 signaling pathway.
Li Li has completed her PhD from Peking University Health Science Center and MD from Capital Medical University in China. She has published more than 15 papers in reputed journals.
Email: lili2009kaoyan@163.com
