Protective effects of Tunisian medicinal plant Salvia officinalis on cytotoxicity, and histological changes in vanadium-induced renal toxicity in rats

11^th International Conference on Nephrology & Urology

March 22-23, 2017 Rome, Italy

Fatma Ghorbel Koubaa, Ahlem Soussi Ben Salah, Mouna Turki, Fatma Makni Ayadi, Mohamed Dammak, Raed Abdennabi, Lassaad Belbhri and Abdelfattah El Feki

University of Sfax, Tunisia
Dammak Pharmacy, Sfax. Tunisia
Laboratory of Pharmacognosy and Natural Products Chemistry Athens 15771, Greece
University of Neuchatel, Switzerland
NextBiotech, 98 Rue Ali Belhouane, 3030 Agareb, Tunisia

Posters & Accepted Abstracts: J Nephrol Ther

Abstract :

Aim: In recent years, there has been an increased interest in vanadium (V) because of its toxicological effects and pro-neoplastic action that affects many organs, specially the kidney. Aim of this study was to evaluate protective effect of medicinal plant on vanadiuminduced renal toxicity in adult male Wistar rats. Methodology: The animals were divided into three groups of six animals each: Group C served as control which received oral gavage with NaCl 0.9%; group V received oral gavage with NaCl 0.9% and injected by vanadium; group SV received oral gavage with essential oil of Salvia officinalis and injected by vanadium for 10 days. Results: Administration of vanadium intraperitoneally for 10 days increased significantly (p<0.05) the levels of serum renal markers [creatinine, urea, blood urea nitrogen (BNU), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) activities and lipid peroxidation thiobarbituric acid reactive substances (TBARS) and protein carbonyl]. Co-administration of the plant essential oil shows a decrease of the tested parameters and an increase of the endogenous antioxidants levels. The vanadium-induced histopathological changes were also minimized with the tested extract. Conclusion: These results suggest that the essential oil of Salvia officinalis might play a role in reducing the toxic effect of vanadium and its biochemical parameters seem to mediate such a protective effect.

Biography :

Email: fatmaghorbelkoubaa@yahoo.fr