alexa Protective Effects Of Vitamins A And E Against Diesel Fuel-induced Hepatotoxicity In Rats
ISSN: 2153-0769

Metabolomics:Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Metabolomics & Systems Biology
March 24-26, 2014 Hilton San Antonio Airport, San Antonio, USA

Friday E. Uboh, Saviour Ufot, Eve Mboso and Patrick E. Ebong
Accepted Abstracts: Metabolomics
DOI: 10.4172/2153-0769.S1.026
Abstract
Diesel fuel has been reported to cause hepatotoxicity in experimental animal models. This study assessed the protective effect of vitamins A and E against diesel fuel-induced hepatotoxicity in rats. Vitamins A (retinol) and E (α-tocopherol), at prophylactic dosage (400 and 200 IU/kg/day, respectively) were orally administered, separately and as combined therapy, to rats orally exposed to 4.0 ml/kg body weight of diesel fuel, once daily for 30 days. Serum lipid profile, including cholesterol, triglycerides, low density lipoproteins (LDL), very low density lipoproteins (VLDL) and high density lipoproteins (HDL); serum liver enzymes, including alanine and aspartate aminotransferases (ALT and AST), alkaline phosphatase (ALP) and gamma glutamyltransferase (GGT) activities; and liver tissue oxidative stress bioindicators, including malondialdehyde, catalase and superoxide dismutase (SOD) activities, were estimated using standard methods. A significant (p<0.05) increase in serum cholesterol, LDL, triglycerides, VLDL, liver tissue malondialdehyde levels, serum ALT, AST, ALP and GGT activities; and a significant decrease in serum HDL level,liver tissue catalase and SOD activities were recorded for rats orally exposed to diesel fuel, compared to control. Concomitant administration of vitamins A and E, respectively, to rats exposed to diesel fuel produced a significant (p<0.05) increase in serum HDL level, liver tissue catalase and SOD activities; decrease in serum cholesterol, triglycerides, LDL, VLDL, liver tissue malondialdehyde levels, serum ALT, AST, ALP and GGT activities; with vitamin E showing a higher potency than vitamin A. However, the effect of combined therapy of vitamins A and E was not significantly different (p>0.05) from that recorded for individual vitamins. The results of this study indicated that vitamins A and E provide protection against diesel fuel-induced hepatotoxicity; and that vitamin E is a more potent antioxidant than vitamin A in rats.
Biography
Friday E Uboh holds BSc, MSc and Ph.D. degrees in Biochemistry (Clincal Biochemistry & Biochemical/Environmental Toxicology) from University of Calabar, Calabar, Nigeria. He is a Senior Lecturer in the Department of Biochemistry,University of Calabar, Calabar, Nigeria. He teaches several Biochemistry courses (including Enzymology, Clinical Biochemistry, Biochemical Toxicology, Tissue Biochemistry Biochemical Methods/Techniques) at the University and supervises a number of graduate and undergraduate students at different departments of the University. He has served in the department as an Examination Officer for 5 years, member of the Departmental Academic Board and Graduate Committee. At present, he is the acting head of the department.His research focus includes several issues on biochemical and environmental toxicology, clinical biochemistry and medicinal plants. He is a member of Nigerian Society for Biochemistry and Molecular Biology (NSBMB) and Institute of Public Analysts of Nigeria (IPAN). He is very prolific in writing and has published many research articles in many reputable scientific journals. He is also a reviewer and member of editorial board in many national and international journals.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords