alexa Protective Role Of Taurine Against Hepatotoxicity Induced By Pyrazinamide In Rats
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

9th Euro-Global Summit on Toxicology and Applied Pharmacology
June 22-24, 2017 Paris, France

Shohreh Taziki
Iran
Posters & Accepted Abstracts: J Clin Toxicol
DOI: 10.4172/2161-0495-C1-025
Abstract
Pyrazinamide is a widely used anti tuberculosis drug. However associated with its clinical use hepatotoxicity as a life treating side effect reported in some patients, but the exact mechanism, by which, Pyrazinamide induces hepatotoxicity is not clear yet. The present investigation was conducted to study the exact mechanism of sub-chronic toxicity induced by pyrazinamide and protective role of taurine in rats. Markers such as ALT and AST levels, lipid peroxidation, ROS formation, hepatocytes glutathione content and apoptosis were examined. Also, pathological changes were evaluated. The Results showed that pyrazinamide administration caused hepatotoxicity as revealed by elevation in ALT and AST levels. Pyrazinamide increased ROS generation and Malondialdehyde derivative levels also it reduced intracellular glutathione contents. Pyrazinamide induced apoptosis in rats liver tissue. Administration of taurine effectively decreased the intensity of hepatotoxicity induced by pyrazinamide in rats.
Biography

Shohreh Taziki is a Researcher working on Toxicology. She is investigating about the exact mechanisms by which drugs (anti-depressants and anti-tuberculosis, etc.) induce hepatotoxicity, such as the process of oxidative stress induced by drugs in isolated rat hepatocytes. The aim of these studies is to reduce the hepatotoxicity induced by various drugs and improving the health.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords