alexa Protein Kinase CK2 Controls T Cell Polarization Through Dendritic Cells Activation In Response To Contact Sensitizers | 63455
ISSN: 1745-7580

Immunome Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

8th Molecular Immunology and Immunogenetics Congress
March 20-21, 2017 Rome, Italy

Saadia Kerdine-Romer
University Paris-Sud, France
ScientificTracks Abstracts: J Immunome Res
DOI: 10.4172/1745-7580.C1.011
Abstract
Statement of the Problem: Allergic contact dermatitis (ACD) represents a severe health problem with increasing worldwide prevalence. It is a T cell-mediated inflammatory skin disease caused by chemicals present in daily or professional environment. Nickel sulfate (NiSO4) and 2, 4-dinitrochlorobenzene (DNCB) are two chemicals involved in ACD. These contact sensitizers are known to induce an up-regulation of phenotypic markers and cytokine secretion in dendritic cells (DCs), professional antigen-presenting cells, leading to the generation of CD8+ Tc1/Tc17 and CD4+ Th1/Th17 effector T cells. Findings: In the present study, using a peptide array approach, we identify protein kinase CK2 as a new kinase involved in the activation of human monocytes-derived DCs (MoDCs) in response to NiSO4 and DNCB. Inhibition of CK2 activity in MoDCs leads to an altered mature phenotype with lower expression of CD54, PDL-1, CD86 and CD40 in response to NiSO4 or DNCB. We also show that CK2 activity regulates pro-inflammatory cytokine production such as TNF-αIL-1β and IL-23 in MoDCs. Moreover, using a DC/T cell co-culture model in an allogeneic set-up, our work demonstrate that CK2 activity in MoDCs plays a major role in the Th1 polarization in response to NiSO4 and DNCB. Interestingly, we also demonstrate that CK2 inhibition in MoDCs leads to an enhanced Th2 polarization in the absence of contact sensitizer stimulation. Conclusion & Significance: CK2 plays: (1) a role in phenotypic maturation and cytokine production in response to NiSO4 and DNCB; and (2) a major role in CD4+ T lymphocytes activation and in the control of Th1 polarization without affecting Th17 polarization.
Biography

Saadia Kerdine-Römer has experience in Immunotoxicology in the field of Skin Allergy. She has been working for many years in the activation of dendritic cells by allergenic molecules. She demonstrated that haptens can be real danger signals. She has worked on the identification of new signaling pathways in immunity cells in response to haptens. Currently, she is working on the transcription factor Nrf2 and its link in the inflammatory response of skin allergic origin.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version