Insulin secretion from the pancreatic beta-cell is regulated principally by the ambient concentration of
glucose. However, the molecular and cellular mechanisms underlying the stimulus-secretion coupling
of glucose-stimulated insulin secretion [GSIS] remain only partially understood. Emerging evidence from
multiple laboratories suggests key regulatory roles for GTP-binding proteins [G-proteins] in the cascade
of events leading to GSIS. This class of signaling proteins undergoes a series of requisite post-translational
lipidation [e.g., prenylation] by a group of enzymes referred as prenyltransferases.
Anjan Kowluru is Associate Dean and Professor Pharmaceutical Sciences and Medicine at Wayne State University.
He also holds Senior Research Career Scientist position at the John D. Dingell VA Medical Center in Detroit. Dr. Kowluru
is involved in understanding regulatory roles of small G-proteins in islet function in health and diabetes. He published
more than 125 papers and presented 225 papers at various local, regional, national and international meetings. His
research is supported by grants from the NIH, the Department of VA and other private foundations including the ADA and
the JDRF. He serves [or served] on scientific advisory panels at the NIH, the VA, the ADA and the JDRF. He is currently
serving [or served] on the editorial boards of several journals, including Endocrinology, Biochemical Pharmacology,
American J. Physiology-Endocrinology and Metabolism, Experimental Diabetes Research and the Journal of Diabetes
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