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Protein-based Biodegradable Microspheres Can Isolate Progenitor Cells And Support Their Proliferation And Differentiation In Suspension And Serve As Cell Carriers For Tissue Regeneration | 5287
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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Protein-based biodegradable microspheres can isolate progenitor cells and support their proliferation and differentiation in suspension and serve as cell carriers for tissue regeneration

International Conference & Exhibition on Cell Science & Stem Cell Research

Raphael Gorodetsky

Accepted Abstracts: J Cell Sci Ther

DOI: 10.4172/2157-7013.S1.16

In spite of the availability of a wide selection of diff erent types of stem cells and the development of sophisticated biopolymers scaff olds, cells impregnated in implanted 3D structures suff ocate and hardly survive and integrate in the damaged tissues following their implantation. We have presented an alternative approach using solid and slowly biodegradable fi brin microbeads (FMB) which were shown to isolate faster mesenchymal stem cell (MSC) from diff erent sources with higher yield than conventional methods. Cells loaded on FMB can expand in-vitro in suspension culture in slow rotation without passages and then be driven to diff erentiate to the cells needed to repair the target organ. Eventually the slowly degrading non- immunogenic FMB could be serve as cells carriers for their minimally invasive implantation with higher survival rate. Th is approach has yielded promising results in bone regeneration animal models using MSC from diff erent sources isolated by FMB to repair critical bone defects. Th is was also proven eff ective for cartilage diff erentiation from MSC. Progenitor cells could also be isolated effi ciently with FMB from other sources such as fat. We recently showed that matrix dependent cells, including MSC, on FMB can survive for prolonged time intervals of weeks only by being sealed in atmosphere-free vials at room temperature. Th ese fi ndings may have major implications in regenerative medicine based on adult progenitor cells and delivery of cells from the bench to the bed-side. In addition, we propose the mechanism for cell binding to fi brin based matrices, which explains the binding of matrix dependent cells to FMB.
Professor Raphael Gorodetsky received his BSc, MSc and Ph.D form the Hebrew University, Jerusalem, followed by a postdoc and research position at UCLA Medical Center. In the last 20 years he heads the Laboratory of Biotechnology and Radiobiology at Hadassah Hospital (af fi liated to the Hebrew University). Among his research interests is the fi eld of adult stem cells based tissue regeneration. His inventions set the basis for co-founding Hapto Biotech where he served as a chief scientist (later acquired by Forticell). Published 95 papers in reputed journals and recently edited a book on Stem Cells and Tissue Repair (RSC Cambridge, UK)
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