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Pulmonary surfactant protein SP-D is a carbohydrate and charge pattern recognition molecule that is a potent link between
innate and adaptive immunity. We have shown previously that a recombinant fragment of human SP-D (rhSP-D) can down
regulate immunological characteristics of allergy in murine model. The protective mechanisms include lowering the levels of IgE,
suppression of eosinophilia and lung infiltration, reduction in airway hyperreactivity, and polarization of Th2 to Th1 immune
response. We have now used in vitro, in vivo and ex vivo systems to dissect the underlying mechanisms through which SP-D
offers resistance against allergenic challenge. We have recently also used proteomic and microarray profiling to characterize
molecular mechanisms and pathways that are modulated by SP-D. These data will be discussed.
Uday Kishore carried out his Ph.D. research from Delhi University, India and post-doctoral training at the Salk Institute, California and the University
of Oxford, UK. He has been the recipient of fellowships/awards from the NASA, Wellcome Trust, Humboldt Foundation, Medical Research Council
and European Commission. He has authored over 80 peer-reviewed research papers, 10 book chapters, 2 international patents, edited two books,
and is currently writing a text book on host-pathogen interaction (Wiley-Blackwell). His research interests include understanding the roles of
innate immunity (including complement system) in allergy, host-pathogen interaction, pregnancy, neuroinflammation and neurodegeneration, and
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