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After human genome is decoded, the characterization of the proteins is the next challenging
task. Unlike genomic studies where individual changes may not have functional
signifi cance, protein expression is closely aligned with cellular function and activity. Th e
proteomic profi ling of functionally important regulatory proteins in cancer cells may shed light
on the understanding of the molecular mechanisms of cancer development and metastasis.
Uncovering the underlying protein signaling network changes in cancer aids in understanding
the molecular mechanism of carcinogenesis and identifi es the characteristic signaling network
signatures unique for diff erent cancers and specifi c cancer subtypes. Th e identifi ed signatures
can be used for cancer diagnosis, prognosis, and personalized treatment. During the past several
decades, several proteomic approaches have been adopted to identify some signaling proteins
and to help us understand their structure, function, and clinical signifi cances in various cancers.
We recently developed a powerful proteomic approach called Protein Pathway Array (PPA)
analysis that allows identifying the important, but low abundance proteins and phosphoproteins
in various cancers. In recent years, using proteomic approaches, we and others have identifi ed
various cancer biomarkers in diagnosis, prognosis and therapeutic target identifi cation in various
cancers. Th is presentation summarizes the usage of proteomics in recent years as an important
technique in defi ning the proteome of cancer, which has helped in elaborate understanding of
the diseases and has provided new avenues for developing better therapeutics and prognosis.
Fei Ye has completed her Ph.D at the age of 31 years from Norman Bethune University of Medical Sciences
(NBUMS) in China and postdoctoral studies from Tongji Medical University in China. She is the assistant
director of Molecular Pathology Division and assistant professor of Department of Pathology at Mount Sinai
School of medicine. She has published more than 30 papers in reputed journals and serving as a reviewer of
several repute journals including Cancer Letters and Cancer Investigation.
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