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Proteomic Patterns Of Colonic Mucosal And Submucosal Tissues Delineates Crohn?s Colitis And Ulcerative Colitis | 8977
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Proteomic patterns of colonic mucosal and submucosal tissues delineates Crohn?s colitis and ulcerative colitis

3rd International Conference on Proteomics & Bioinformatics

Amosy E. M\\\'Koma

ScientificTracks Abstracts: J Proteomics Bioinform

DOI: 10.4172/0974-276X.S1.067

Purpose: Although Crohn?s colitis (CC) and ulcerative colitis (UC) share several clinical features, they have different causes, mechanisms of tissue damage, and treatment options. Therefore, the accurate diagnosis is of paramount importance in terms of medical care. The distinction between UC/CC is made on the basis of clinical, radiologic, endoscopic, and pathologic interpretations but cannot be differentiated in up to 15% of IBD patients. Correct management of this ?indeterminate colitis? (IC) depends on the accurate diagnosis. Experimental design: We have developed a proteomic methodology that has the potential to discriminate between UC/CC. The histologic layers of 99-confirmed UC/CC tissues were analyzed using MALDI-MS for proteomic profiling. Results: Eight-protein-signatures differentiated UC/CC. These signals are independent of the tissue of origin and represent potential disease specific markers. Some of these signatures are primarily found in the colonic mucosa and would be amenable to proteomic interrogation from endoscopic biopsies. Others are primarily submucosal and have the potential to become amenable to proteomic studies in the serum. Some protein-signatures were found in both two layers. Conclusion/Clinical relevance: This information may provide new-avenues for the development of novel evidenced personalized therapeutic targets.
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