alexa Protracted Protection Against Malaria Is Maintained By Memory T Cells
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Clinical & Cellular Immunology
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Urszula Krzych
Accepted Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.019
Abstract
Immunologic memory is one of the cardinal features of adoptive immune responses and is inextricably linked to lasting protection against infections. While many re-infections are prevented by memory T and B cells, malaria re-infections occur frequently and the reasons for the absence of lasting protection in endemic areas remain poorly understood. By contrast, exposures of humans and laboratory rodents to radiation-attenuated Plasmodium sporozoites (γ-spz) induce sterile and durable protection against experimental sporozoite challenge. The presence of memory CD4 T cells has been shown to be associated with lasting protection in humans exposed P. falciparum (Pf) γ -spz. Studies focusing on durable protection induced in mice with P. yoelii and P. berghei γ -spz have, instead, implicated memory CD8 T cells as crucial features of lasting protection. We observed that in the Pb γ -spz model, MHC class I-dependent liver-stage (LS) Ag-specific memory CD8 T cells are indispensable for the maintenance of protection. We hypothesize that long-term protection to malaria, whether mediated by CD8 or CD4 T cells, can be induced and maintained. As such, it requires the formation and persistence of memory T cells with a reservoir of central memory cells maintained in part by LSAg-depot, IL-15 and possibly IL-4 and other cytokines that promote conscription of IFN-γ producing effector/effector memory CD8 T cells during re-infections.
Biography
Urszula Krzych received her PhD degree from Rutgers University and subsequently as a Postdoctoral fellow studied with the late Eli Sercarz at UCLA. She currently heads the Department of Cellular Immunology at WRAIR, where she has been conducting research on the various aspects of malaria, most notably investigating immune mechanisms of protection induced by malaria vaccines in humans and mice. She is also affiliated with the George Washington University, Washington, DC.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords